Abstract 11861: Ethnic Differences in the 10-Year Risk of Coronary Heart Disease Among High Risk Individuals in a Large Contemporary Population
Purpose: To evaluate ethnic differences in CHD risk in high risk patient populations in 4 study cohorts: 1) No diabetes (DM) and no prior CHD 2) DM but no prior CHD, 2) non-DM with prior CHD and 3) DM with prior CHD.
Methods: 1,586,061 members of an integrated health care system, with self reported race/ethnicity of Asians (14.1%), blacks (8.6%), Latinos (12.6%), and whites (64.5%), ages 30- 90 years, were evaluated from 01/01/2002 through 12/31/2011. We specified Cox proportional hazard models and compared the Hazard Ratios (HRs), relative to that of whites, for incident CHD in the 4 study cohorts.
Results: The median follow up time for this cohort was ten years (10,980,800 person years). Figure shows the age and sex adjusted (squares) hazard ratios (relative to that of whites) for CHD for Blacks, Latinos and Asians, respectively for the 4 study groups. These age and sex-adjusted effect estimates were not altered substantively by further adjustment for smoking, HTN, lipid levels and statin use (figure, circles). However a slightly higher risk (HR of 1.15 95%, CI, 1.05-1.27) was noted among Blacks with prior CHD and no DM. No increase risk was noted in blacks with both DM and CHD.
Conclusions: In this integrated delivery system with uniform medical care coverage, we observed slightly reduced risk or no difference in risk for Blacks, Asians, and Latinos compared to whites in all 4 risk groups, and observed a greater risk of CHD for Blacks without prior DM but with previously diagnosed CHD. These findings may inform policy development and interventions designed to identify and eliminate disparities.
Author Disclosures: J.S. Rana: None. J. Liu: None. H.H. Moffet: None. M. Jaffe: None. A.J. Karter: None.
- © 2014 by American Heart Association, Inc.