Abstract 11744: Home-Based Exercise Improves Walking Speed and Prevents Mobility Loss in Peripheral Artery Disease: A Randomized Controlled Trial
Background: We studied whether a group-mediated cognitive behavioral (GMCB) intervention for peripheral artery disease (PAD) participants, which promoted home-based walking exercise, improved walking speed and prevented mobility loss at six-month follow-up, compared to a control group.
Methods: One hundred ninety-four participants with PAD were randomized to the GMCB intervention vs. an attention control group. Participants randomized to the intervention attended weekly meetings for six months, during which group support and self-regulatory skills were used to help participants adhere to home-based walking exercise. Participants randomized to the control group attended weekly lectures about health topics not related to exercise. Primary outcomes have been reported. Here we report the exploratory outcomes of mobility loss, normal and fast-pace walking velocity, and change in the Short Physical Performance Battery (SPPB) at 6-month follow-up. Mobility loss was defined as becoming unable to walk up and down one flight of stairs or walk ¼ mile without assistance. Mobility analyses were limited to participants without mobility loss at baseline.
Results: One hundred seventy-eight (91.7%) of the 194 randomized participants completed 6-month follow-up. Participants had a mean age of 70.66 years +9.44, a mean ABI of 0.67+0.17 and included 50.6% females and 48.8% African-Americans. The intervention group had less mobility loss than the control group (6.25% vs. 26.47%, odds ratio: 0.19, 95% CI: 0.06 to 0.58, P=0.002). The three other exploratory outcomes are shown in the table below.
Conclusions: A GMCB intervention designed to help PAD patients adhere to home-based walking exercise dramatically reduced mobility loss and improved the fast-paced 4-meter walking velocity at 6-month follow-up, compared to a control group.
Author Disclosures: M. McDermott: None. M. Criqui: None. K. Domanchuk: None. J. Guralnik: None. M. Kibbe: None. K. Liu: None. Y. Liao: None. D. Lloyd-Jones: None. B. Spring: Consultant/Advisory Board; Modest; Actigraph Scientific Advisory Board. L. Tian: None. L. Zhao: None. W. Rejeski: None.
- © 2014 by American Heart Association, Inc.