Abstract 11642: Exposure to Fine Particulate Matter is Associated With Progression of Subclinical Atherosclerosis: Systematic Review and Meta-Analysis
Introduction: Individual studies have suggested an association between exposure to fine particulate matter (PM with aerodynamic diameter ≤2.5μm [PM2.5]) and atherosclerosis progression using carotid intimal medial thickness (CIMT), but their generalizability is limited. We therefore conducted a systematic review and meta-analysis of available literature in order to investigate the association of PM2.5 and atherosclerosis as measured by CIMT across multiple studies.
Hypothesis: PM2.5 exposure is associated with atherosclerosis progression by CIMT.
Methods: We performed a comprehensive search for studies published up to 3/2014 (Medline, Embase, Web of Science, Environmental Index) that evaluated any association between exposure to PM 2.5 and change in CIMT. Studies were selected based on predefined inclusion criteria. 5 authors reviewed eligible manuscripts and 2 authors independently extracted the data. We estimated the mean change in CIMT per 10μg/m2 increase in PM 2.5. Using random effects models, pooled mean change estimates in CIMT with their 95% confidence intervals (CIs) were calculated. Between-study heterogeneity was evaluated with the I2 statistic, and publication bias was assessed with funnel plot and Egger’s test.
Results: The final sample included 9 studies with 24,585 individuals. Pooled estimates showed a mean increase of 15.57 μm in CIMT (95% CI 5.75-25.40) per 10 μg/m3 increase in PM2.5 exposure (Figure 1). There was significant between-study heterogeneity (I2=78.2% , P<0.001). Egger’s test suggested the presence of publication bias (P=0.035) towards studies with positive results.
Conclusions: Our meta-analysis supports a relationship between fine particulate matter and atherosclerosis progression by CIMT across multiple studies, although studies are heterogeneous and there is potential publication bias towards positive results.
Author Disclosures: E. Akintoye: None. L.H. Shi: None. I. Obaitan: None. M. Olusunmade: None. Y. Wang: None. J.A. Dodson: None.
- © 2014 by American Heart Association, Inc.