Abstract 11530: Age-Specific Differences Between Conventional and Ambulatory Daytime Blood Pressure Values
Introduction: Mean daytime ambulatory blood pressure (ABP) values are considered to be lower than conventional BP (CBP) values, but data on this relation among younger individuals <50 years are scarce. To address this issue, we performed a collaborative analysis in a large group of participants representing a wide age range.
Methods: CBP and 24-hour ABP were measured in 9550 individuals not taking BP lowering treatment from 13 population based cohorts. We compared the individual differences between daytime ABP and CBP according to 10-year age categories. Age-specific prevalences of white-coat hypertension and masked hypertension were calculated based on guideline-recommended thresholds.
Results: Among individuals aged 18-30, 30-40 and 40-50 years, mean daytime systolic and diastolic ABP were significantly higher than the corresponding CBP (6.0, 5.2 and 4.7 mmHg for systolic BP; 2.5, 2.7 and 1.7 mmHg for diastolic BP, all p<0.0001) (Figure). Systolic and diastolic BP indices were similar in participants aged 50-60 years (p=0.20 and 0.11, respectively). In individuals aged 60-70 and ≥70 years, CBP was significantly higher than daytime ABP (5.0 and 13.0 mmHg for systolic BP; 2.0 and 4.2 mmHg for diastolic BP, all p<0.0001) (Figure). Accordingly, the prevalence of white coat hypertension exponentially increased from 2.2% to 19.5% from those aged 18-30 years to those aged ≥70 years, with some variation between men and women (prevalence 8.0% versus 6.1%, p=0.0003). Masked hypertension was more prevalent among men (21.1% versus 11.4%, p<0.0001). The age-specific prevalence of masked hypertension was 18.2%, 27.3%, 27.8%, 20.1% 13.6% and 10.2% in men, and 9.0%, 9.9%, 12.2%, 11.9%, 14.7% and 12.1% in women.
Conclusions: In this large collaborative analysis we found that the relation between daytime ABP and CBP strongly varies by age. These findings may have important implications for the diagnosis of hypertension and its subtypes in clinical practice.
Author Disclosures: D. Conen: None. S. Aeschbacher: None. L. Thijs: None. Y. Li: None. J. Boggia: None. K. Asayama: None. T.W. Hansen: None. M. Kikuya: None. K. Björklund-Bodegård: None. T. Ohkubo: None. J. Jeppesen: None. Y. Gu: None. C. Torp-Pedersen: None. E. Dolan: None. T. Kuznetsova: None. K. Stolarz-Skrzypek: None. V. Tikhonoff: None. T. Schoen: None. S. Malyutina: None. E. Casiglia: None. Y. Nikitin: None. L. Lind: None. E. Sandoya: None. K. Kawecka-Jaszcz: None. L. Mena: None. G.E. Maestre: None. J. Filipovsky: None. Y. Imai: None. E. O’Brien: None. J. Wang: None. L. Risch: None. J.A. Staessen: None.
- © 2014 by American Heart Association, Inc.