Abstract 11419: Subclinical Arterial Remodeling of Thoracic Aorta in Subjects Without Cardiovascular Events: A Magnetic Resonance Imaging Study
Background: Arterial remodeling is thought to be implicated in the pathogenesis of vascular diseases such as atherosclerosis and aneurysm. Although a phenomenon known as positive remodeling has been observed in the coronary artery, the remodeling patterns of other arterial beds remain poorly understood. By delineating vessel wall morphology noninvasively, cardiovascular magnetic resonance (MR) may afford a unique opportunity to study arterial remodeling in the general population. Using MR imaging, we sought to examine the remodeling pattern of thoracic aorta in a large cohort of subjects free of prior cardiovascular events.
Methods: This study was a branch of High-Risk Plaque(HRP) Initiative. Three hundred and seventy-seven subjects, with no cardiovascular events but a broad spectrum of cardiovascular risk factors, were recruited. Two-dimensional MR imaging of the thoracic aorta was performed from aortic arch to the diaphragm level. Lumen area, total vessel area, and mean wall thickness were measured on each slice and then averaged per subject. General linear models were used to examine any influence of cardiovascular risk factors and wall thickness on lumen area and total vessel area after adjustment for gender and body habitus.
Results: The mean age was 67.5± 6.1; 50.3% subjects were males; and 80% had at least one traditional risk factor. The average mean wall thickness was 1.79±0.15 mm. After adjusting for gender and body habitus, aging (p<0.001) and hypertension (p=0.012) were significantly associated with increase in both lumen area and total vessel area. In contrast, increase in mean wall thickness did not show an impact on lumen area (p=0.908) whereas it led to significant enlargement of total vessel area (p=0.004). Furthermore, an interaction between hypertension and wall thickness was noted on both lumen area and total vessel area, indicating reduced capability of outward remodeling in the presence of hypertension.
Conclusions: Arterial remodeling of thoracic aorta was found with MR imaging in an asymptomatic cohort without cardiovascular events. Overall vessel size expanded with aging and in the presence of hypertension while wall thickening induced positive remodeling without affecting lumen.
Author Disclosures: Y. Song: None. J. Sun: None. D.S. Hippe: None. N. Balu: None. X. Zhao: None. F. Li: None. T. Hatsukami: None. C. Yuan: None.
- © 2014 by American Heart Association, Inc.