Abstract 11417: Obstructive Sleep Apnea and Progression of Coronary Artery Calcium: The MESA Study
Background: Obstructive sleep apnea (OSA) is a common condition associated with cardiovascular disease. Its potential effect on progression of subclinical atherosclerosis is not well understood. We tested a hypothesis that OSA is associated with progression of coronary artery calcium (CAC). We also evaluated whether traditional cardiovascular risk factors accounted for the association.
Methods: In the Multi-Ethnic Study of Atherosclerosis (MESA) prospective cohort, we studied 2,603 participants who at baseline completed a sleep questionnaire and underwent coronary computerized tomography (CT), and 8 years later a repeat coronary CT. Participants were categorized by symptoms of habitual snoring or reported physician diagnosis of OSA.
Results: At baseline, 102 (3.9 %) reported diagnosed OSA; 666 (25.6 %) habitual snoring; and 1835 (70.5 %) with neither habitual snoring nor OSA (“normal”). The highest CAC prevalence was among those with OSA. CAC prevalence was similar for those with and without habitual snoring or OSA. Over 8 years of follow-up, greater progression of CAC was observed in a demographics, behavior and body habitus adjusted model among those with OSA vs. normal (mean increase of 204.2 vs.135.5Agatston units). Modest attenuation was observed after adjustment for cardiovascular risk factors (188.7 vs. 138.8; p = 0.06). CAC progression among habitual snorers was similar to that observed in the normal.
Conclusion: Self-reported OSA was associated with CAC score progression after adjustment for demographics, behaviors and BMI. However, the association was not significant after accounting for cardiovascular risk factors which may mediate the association between OSA and CAC.
Author Disclosures: Y. Kwon: None. D. Duprez: None. D.R. Jacobs: None. M. Nagayoshi: None. R.L. McClelland: None. E. Shahar: None. M. Budoff: None. S. Redline: None. S. Shea: None. J.J. Carr: None. P.L. Lutsey: None.
- © 2014 by American Heart Association, Inc.