Abstract 11279: Heart Type Fatty Acid-Binding Protein is a Factor for Predicting Concomitant Presence of Coronary Artery Disease in Patients With Abdominal Aortic Aneurysms
Introduction: Abdominal aortic aneurysm (AAA) is not unusual to find such aneurysms accompanied by coronary artery disease (CAD). However, no risk factors that allow the prediction of accompanying CAD among AAA patients have yet been identified. Heart type fatty acid-binding protein (H-FABP) is available as indicators of myocardial damage. Recent reports suggest that H-FABP can be a factor for predicting the severity and prognosis in patients with CAD. This study dissected AAA cases and considered whether H-FABP may be a predictive factor in the concomitant presence of CAD.
Methods: The study focused on 90 patients awaiting surgery for AAA, who underwent coronary angiography examinations for the purpose of undergoing the detailed examination of the coronary artery. H-FABP and a range of other blood sampling markers were measured, and the patients were divided into groups according to the concomitant presence of CAD.
Results: Forty cases tested positive for CAD. The H-FABP of the CAD group was compared with that of the non-CAD group, and found to be significantly higher (4.85±2.32 vs. 3.81±1.40 p<0.01). H-FABP rose significantly in line with an increase in the number of coronary lesions. According to a multivariable analysis, H-FABP was an independent risk factor for concomitant CAD.
Conclusions: These results suggest that measuring the H-FABP may be an effective method for stratifying the risk of concomitant CAD among patients with AAA.
Author Disclosures: A. Funayama: None. T. Watanabe: None. Y. Otaki: None. S. Nishiyama: None. H. Takahashi: None. T. Arimoto: None. T. Shishido: None. T. Miyamoto: None. I. Kubota: None.
- © 2014 by American Heart Association, Inc.