Abstract 11253: EF<50% Strongly Predicts Abnormal PET/CT Imaging Results in Patients Being Evaluated for Cardiac Sarcoidosis
Background: 18F-FDG positron emission tomography (PET) along with 82Rubidium radiotracer imaging is a non-invasive semi-quantitative technique that aids in the diagnosis of cardiac sarcoidosis, as defined by the Japanese Ministry of Health and Welfare Criteria (JMHC). The study’s objective was to identify characteristics in cardiac presentation associated with positive PET results.
Methods: We retrospectively analyzed 83 patients with proven or suspected cardiac sarcoidosis, referred for PET imaging between 2009-2013. PET scans were classified as normal or abnormal with positive FDG uptake and/or Rubidium perfusion defect. Multivariate logistic regression analysis adjusted for age, race, gender, HTN, DM, and CAD was performed to assess PET results as associated with significant baseline cardiac characteristics.
Results: Mean age was 54 + 12 years, 60% were male, 6% had CAD, 4.8% were survivors of SCD, 12% had AICD discharges for VT, 21.7% had sustained VT and 48.2% had CHF. 55.4% of patients had abnormal FDG uptake in the heart. Significant predictors for a positive PET scan are shown in the Table.
Conclusion: Patients with suspected or known cardiac sarcoidosis and EF<50% are 7 times more likely to have an abnormal FDG uptake in the heart compared to those with normal EF. Additionally, the likelihood of having an abnormal FDG and/or Rb-82 PET study is significantly increased for patients with a history of CHF, AICD discharge, atrial fibrillation, wall motion abnormalities, ventricular aneurysm or wall thickening. This information is valuable to clinicians in referring patients with proven or suspected sarcoidosis for PET imaging to determine optimal medical treatment.
Author Disclosures: V. Bazylevska: None. H.H. Feringa: None. S. Venkata: None. L. Bellumkonda: None. R.R. Russell: None. D. Jacoby: None.
- © 2014 by American Heart Association, Inc.