Abstract 11178: Effect of Female Gender on Acute Coronary Syndrome Outcomes in Young Patients
Background: Recent reports have suggested that there are gender differences in the presentation of young adults with acute coronary syndromes (ACS). How these differences may affect ACS outcomes remains unclear, however. The aim of the current study was to examine the prognostic impact of gender in young adults with ACS in a multicenter multinational ACS registry from the Middle East.
Methods: For a period of 9 months in 2008 to 2009, 7,930 consecutive patients with ACS were enrolled from 65 hospitals in 6 Middle East countries. A cohort of 3933 patients in the age group 55 years and younger were selected of whom 552 were women (14%). Gender differences in presentation and clinical features were examined. Multivariate analysis of in-hospital and one year mortality was also performed.
Results: The mean age for women was 46 years and for men 48 years. Women had significantly higher rates of diabetes mellitus (50.4% vs. 30.7%), hypertension (57.4% vs. 34.5%), obesity (32% vs. 17%), dyslipidemia (37.5% vs. 26%) and renal impairment (4.1% vs. 1.2%) whereas men were more likely to be smokers (72.4% vs. 14%) [all P<0.001]. Compared to men, women had an increased in-hospital and 1-year mortality rates (3.6% vs. 2.2%, p=0.04, and 9.7% vs. 6.5%, p=0.02, respectively). In multivariate analysis, female gender was an independent predictor of in-hospital mortality (OR, 1.88 [95%CI, 1.02-3.45]; P=0.04) and one year mortality (OR, 1.82 [95%CI, 1.18-2.78]; P=0.007).
Conclusions: Our study shows that female gender independently and significantly increases the risk of immediate and long term mortality in young patients with ACS.
Author Disclosures: A.M. Salam: None. K. AlHabib: None. W. Almahmeed: None. A. Alsheikh-Ali: Other Research Support; Modest; Medtronic, Behringer Ingelheim. Honoraria; Modest; Boehringer Ingelheim, Bayer, Pfizer. K. Sulaiman: None. H. Amin: None. A. Al-Motarreb: None. J. Al-Lawati: None. N. Asaad: None. R. Singh: None. J. Al-Suwaidi: None.
- © 2014 by American Heart Association, Inc.