Abstract 11149: Efficacy of Statin Therapy for Inducing Coronary Plaque Regression in Patient With Low Cholesterol Level
Introduction: Statin therapy induces coronary plaque regression and cardiovascular events; however, the efficacy for the patients with low serum cholesterol level is still controversial. The present study was therefore conducted to assess the relationship between serum cholesterol level at baseline and coronary plaque regression by statin therapy, using serial intravascular ultrasound (IVUS) data from the TRUTH (treatment with statin on atheroma regression evaluated by IVUS with virtual histology) study.
Hypothesis: Statin therapy may not induce coronary plaque regression in patient with low cholesterol level at baseline.
Methods: The TRUTH study evaluated the effects of 8-month statin therapy on coronary atherosclerosis in 164 patients. All patients were statin naïve and were started statin therapy after enrollment. The primary end point of the present study was % coronary plaque volume change in IVUS.
Results: Serial IVUS data, baseline and 8-month follow-up, was available for 119 patients. The patients were divided into 3 groups based on non HDL cholesterol level (low≦140 mg/dl, n=38: moderate 141-169, n=42: high ≧170, n=39). Coronary plaque progressed in low cholesterol group while plaque regression was observed in the other groups (ANOVA, p=0.012) (Figure). After adjustment for all variables, low non HDL cholesterol level (≦140 mg/dl) was the independent predictor of coronary plaque progression [odds ratio 4.1, 95% CI:1.6-10.8, p=0.004].
Conclusion: Statin therapy for inducing coronary plaque regression is less effective in patient with low cholesterol level and more effective in patients with high cholesterol level. Additional interventions are needed for coronary atery disease patients with low cholesterol.
- Coronary artery disease
- Cardiovascular disease prevention
- Intravascular ultrasound/Doppler
Author Disclosures: K. Wakabayashi: None. T. Nozue: None. S. Yamamoto: None. S. Tohyama: None. K. Fukui: None. S. Umezawa: None. Y. Onishi: None. T. Kunishima: None. A. Sato: None. S. Miyake: None. Y. Morino: None. T. Yamauchi: None. K. Hibi: None. T. Muramatsu: None. T. Sozu: None. M. Terashma: None. H. Suzuki: None. I. Michishita: None.
- © 2014 by American Heart Association, Inc.