Abstract 11040: Not Carotid but Femoral Artery Intima-Media Thickness Predicts Peripheral Artery Disease in Patients With Coronary Artery Disease
Background: Numerous studies reported the clinical and prognostic significance of carotid artery intima-media thickness (IMT) in atherosclerotic disease patients. However, clinical significance of femoral artery IMT was not fully elucidated. Femoral artery IMT may have unique clinical significance in patients with coronary artery disease (CAD).
Purpose: We examined the relationship among carotid and femoral artery IMT, the presence of PAD, and risk factors in fully medically treated patients with CAD.
Methods: Patients (n = 192; mean age 71.8±10.4 years) who were diagnosed by coronary angiography were enrolled. PAD was defined as ABI < 0.9. Using ultrasound echo, the mean common carotid and femoral artery IMT were evaluated. We evaluated the diagnostic value of the carotid and femoral artery IMT for PAD. To determine the cutoff value of IMT for prediction of PAD, we used a receiver operating characteristic (ROC) analysis. Furthermore, we examined the differences of risk factors for the increased IMT in both carotid and femoral arteries. A logistic regression analysis was used.
Results: Femoral IMT was significantly higher in patients with PAD than in those without PAD (2.27[1.91-2.74] vs. 1.60[1.19-2.05]mm, P<0.001). On the other hand, there was no correlation between carotid IMT and PAD (0.79[0.65-1.02] vs. 0.77[0.64-0.94]mm, P=0.516). The ROC curve analysis revealed that the optimal cutoff values for predicting PAD was 1.78 mm for the mean femoral IMT level (Figure). A multivariate logistic analysis revealed that MDA-LDL level of ≥84 mg/gCr and age ≥72 years were independent predictors of increased mean femoral IMT (Odds ratio [95%CI]: 2.78 [1.51-5.12] and 1.89 [1.02-3.52], respectively). There were no significant risk factors for increased carotid IMT.
Conclusion: Not carotid artery but femoral artery IMT predicts PAD in patients with CAD. Risk factors for increased femoral IMT were high value of MDA-LDL and aging.
- Intravascular ultrasound/Doppler
- Peripheral artery disease (PAD)
- Ankle-brachial index (ABI)
- Coronary heart disease
Author Disclosures: N. Okumura: None. M. Saito: None. T. Tanaka: None. M. Matsumoto: None. M. Tsuzuki: None. T. Murohara: None.
- © 2014 by American Heart Association, Inc.