Abstract 10976: Parent-Offspring Association of Metabolic Syndrome in the Framingham Heart Study
Introduction: Metabolic syndrome (MS) is a clustering of five metabolic risk factors including abdominal obesity (OB), elevated blood pressure, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and impaired fasting glucose (IFG). Few studies have fully reported the strength of clustering of these risk factors in a parent-offspring relationship. This analysis describes the associations between parents and their adult offspring in regard to MS. It also estimates the association between each risk factor in parents and the presence of MS in their offspring.
Methods: We analyzed data for 1193 offspring (565 sons, and 628 daughters) from the Framingham Offspring Study who attended examinations 5, 6, and 7. Information about their parents was collected from examinations 13, 14 and 15 of the Framingham Original Cohort study. We used pedigree file to combine parental and offspring’s data. Participants were classified as having the MS according to the Adult Treatment Panel III criteria. Logistic regression was used to estimate the associations.
Results: After adjusting for age, education, smoking, alcohol consumption and physical activity level of offspring, no significant association was found between fathers’ and their offspring’s MS. Mothers’ MS was significantly and positively associated with their daughters’ MS (adjusted odds ratio or adj OR:1.63; 95% confidence Interval, CI:1.02-2.61), but not with their sons’ MS. This gender difference was not observed when both the parents had MS. Daughters (adj OR:4.13; 95% CI:1.31_13.07) and sons (adj OR:4.31; 95% CI:0.98-19.77) both had more than 4 folds of increased odds of having MS if both parents had MS compared to offspring whose neither parent had MS. When analyzed by individual components, mothers’ IFG (adj OR:2.03 ; 95% CI:1.02- 9.31), OB (adj OR:1.56; 95% CI:0.98- 2.55) and HDL-C (adj OR: 2.12; 95% CI:1.35-3.32) were associated daughters’ MS. But none of these were significant for their sons’ MS. For fathers, only IFG (adj OR:4.91; 95% CI:2.07- 11.68) was associated with their daughters’ MS.
Conclusions: We found differential associations between parents and their adult offspring in regard to MS. Daughters with mother’s MS were in higher risk than daughters or sons with father’s MS.
Author Disclosures: R.J. Khan: None. C.N. Rotimi: None. S.Y. Gebreab: None. P.R. Crespo: None. R. Xu: None. S.K. Davis: None.
- © 2014 by American Heart Association, Inc.