Abstract P432: Effects of Weight Management by Exercise Mode on Subclinical Atherosclerosis for Women with Abdominal Obesity: A Randomized Controlled Trial
Purpose: Few studies have examined differential effects of weight management by exercise mode on subclinical atherosclerosis. We hypothesized that exercise modes of aerobic, resistance, and combination exercises would have differential effects on endothelial dysfunction, aortic stiffness, and carotid intima-media thickness (IMT) in a weight management intervention.
Methods: We conducted a randomized controlled trial in which 110 sedentary women with abdominal obesity were enrolled in a 12-month weight management program between September 2010 and November 2011. Fifty participants were randomly assigned to an aerobic training group, 30 to a resistance training group, and 30 to a combined aerobic and resistance training group. The weight management had a diet-alone intervention for the first 3 months and a diet-plus-exercise intervention for the next 9 months according to exercise modes. Exercise training was designed for three days per week in 60-minute sessions and a gradual increase in exercise intensity using % heart rate reserve. Flow-mediated dilation (FMD), carotid-femoral pulse wave velocity (PWV), and carotid IMT were measured at 0, 3, 6, 9, and 12 months.
Results: Participants had a mean age of 43.1 years and a mean body mass index of 28.5 kg/m2. After a 12-month intervention, participants experienced a weight loss of approximately 5%. Changes in FMD, PWV, and IMT did not differ significantly by exercise mode, but PWV and IMT were significantly reduced over the diet-plus-exercise intervention.
Conclusion: Among women with abdominal obesity, the effects of weight management on subclinical atherosclerosis did not differ by exercise mode, but its effects on aortic stiffness and carotid IMT may be beneficial over time.
Author Disclosures: J. Choo: None. J. Lee: None. A. Sekikawa: None. L.E. Burke: None. S. Jae: None.
- © 2014 by American Heart Association, Inc.