Abstract P425: Frequency of Nut Consumption is Associated with Reduced Prevalence of Peripheral Arterial Disease in a Very Large Community Cohort
Introduction: Consumption of nuts may improve lipids, insulin resistance and markers of inflammation, and increased nut intake has been associated with lower risk of coronary and cerebrovascular disease. However, an association between nut intake and peripheral artery disease (PAD) is less certain. The purpose of this analysis was to investigate the association between dietary nut consumption and presence of PAD defined by ankle-brachial index (ABI) <0.9 in a large community cohort.
Methods: Over 3.5 million self-referred participants from 2003-2008 at >20,000 US sites who completed a medical and lifestyle questionnaire were evaluated by screening ankle brachial indices <0.9 for PAD. Subjects were asked about frequency of consumption of a serving of nuts (<1x/month, 1x/month - 1x/week, 2-3x/week, 4-5x/week, and daily). Multivariate logistic regression analysis was used to estimate odds of PAD in different nut consumption categories.
Results: Among 3,503,770 individuals, mean age was 63.6 ±10.6 years and 63% were female. The consumption of nuts ranged from 20% with <1x/month consumption to 15% daily consumption (Figure). After adjustment for age, gender, race/ethnicity, smoking, physical activity, diabetes, hypertension, hyperlipidemia and family history of vascular disease, there was a step-wise inverse association of nut intake with PAD (Figure). Compared to subjects with consumption of nuts <1x/month, daily nut consumption was associated with a 23% lower odds of PAD (OR 0.774, 95% CI 0.761 - 0.787).
Conclusions: We present data from a very large community cohort, in which nut consumption exhibited an inverse step-wise relationship with PAD prevalence after correction for established risk factors for atherosclerosis. These observations suggest the need for more rigorous testing for a role for nuts in PAD prevention.
Author Disclosures: S.P. Heffron: None. C.B. Rockman: None. Y. Guo: None. M. Adelman: None. J.S. Berger: None.
- © 2014 by American Heart Association, Inc.