Abstract P411: Associations Between Dietary Polyunsaturated Fatty Acid Intakes And Serum C-reactive Protein Concentrations In Adults From Nhanes 2003-10
Background: Multiple clinical studies and literature reviews suggest that elevated serum C-reactive protein (CRP) concentration may be associated with risks of cardiovascular diseases (CVD), type-2 diabetes, certain autoimmune disorders, and infection or inflammation. Data are very limited and inconsistent about impact of dietary polyunsaturated fatty acid (PUFA) intakes on CRP concentrations.
Method: PUFA intakes and CRP measurement in adults (aged 19 years and elder) were extracted from databases of NHANES 2003-10. Non-normally distributed data were normalized by log-transformation. SAS survey-mean and survey-regression procedures were used to analyze the dataset extracted. Result: In total, 17,785 participants who had valid CRP and PUFA intake data were included in this work. Means of PUFA intake, CRP concentration, and n6- to n3- fatty acids (FA) ratio were 15.11 g/d (median 15.56 and SE 0.07), 1.79 mg/L (median 1.80, SE 0.006), and 9.81 (median 9.21, SE 0.027), respectively. 38.94% (n=6925) participants had CRP concentration ≥3 mg/L with mean PUFA intake 14.36 g/d, 9.54% (n=1,696) ≥10~>30 mg/L with mean PUFA intake 14.41 g/d, and 1.43% (n=254) ≥30mg/L with mean PUFA intake 12.91 g/d. From regression analyses, CRP concentration was significantly and inversely correlated with PUFA intake (P<0.0001) with adjustment for saturated fat intake, gender, age, and BMI, but not correlated with the ratio of n6 to n3 FA (P=0.57). CRP concentration was also significantly and inversely correlated with PUFA intake quartiles (P=<0.0001) with the same adjustment setting. Least square (LS) mean of CRP concentration in the lowest quartile group (2.06 mg/L) was significantly higher (P= 0.001~<0.0001) than the LS means of all other 3 PUFA intake quartile groups. LS means of CRP concentration in the 2nd lowest and the 3rd quartile groups (1.85 and 1.79 mg/L) were also significantly higher (P=0.005 and 0.046, respectively) than the LS mean of the highest quartile group (1.69 mg/L).
Conclusion: Descriptive statistics and multi-covariate regression showed that dietary PUFA intakes were inversely associated with serum CRP concentration in the adult population, but not associated with n6- to n3- FA ratio. This finding is consistent with previous suggestions that sufficient PUFA or n3 FA intakes may enhance immune function, reduce risk of infection, and infection/inflammation-related diseases, such as CVD. In the population analyzed, intakes of linoleic acid, alpha-linolenic acid, n3 FA, n6 FA, and total PUFA were tightly correlated with each other (r=0.833-0.999, Spearman).
Author Disclosures: S. Sun: A. Employment; Significant; ADM. F. Ownership Interest; Modest; ADM. B. Flickinger: A. Employment; Significant; ADM. F. Ownership Interest; Modest; ADM.
- © 2014 by American Heart Association, Inc.