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Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Information may not be released before then. Failure to honor embargo policies will result in the abstract being withdrawn and barred from presentation.
Poster Abstract PresentationsSession Title: Biomarkers 2

Abstract P349: Association Of Fibroblast Growth Factor 23 With Incident Cardiovascular Disease And All-Cause Mortality In The Framingham Heart Study

Robin Haring, Ramachandran S Vasan, Henri Wallaschofski, Lisa Sullivan, Danielle Enserro
Circulation. 2014;129:AP349
Robin Haring
Boston Univ Sch of Medicine, Preventive Medicine and Epidemiology Section, Boston, MA
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Ramachandran S Vasan
Boston Univ Sch of Medicine, Preventive Medicine and Epidemiology Section, Boston, MA
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Henri Wallaschofski
Univ Medicine Greifswald, Greifswald, Germany
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Lisa Sullivan
Boston Univ Sch of Medicine, Dept of Biostatistics, Boston, MA
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Danielle Enserro
Boston Univ Sch of Medicine, Dept of Biostatistics, Boston, MA
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Abstract

Objective: To investigate the association of fibroblast growth factor 23 (FGF23) with incident cardiovascular disease (CVD) and mortality risk in the general population.

Methods: We evaluated 3,236 Framingham Offspring and Omni Study participants to examine the associations of serum FGF23 (measured by immunoassay) with 10-year incident CVD (N = 2,823) and all-cause mortality (N = 3,223) using multivariable Cox regression models.

Results: During a median follow-up time of 10.8 years (Q1, 10.0; Q3, 11.4), 347 participants developed new-onset CVD and 412 died. Age- and sex-adjusted Cox regression models revealed a positive association of FGF23 with incident CVD (hazard ratio (HR) per unit increase in logFGF23: 1.43, 95% confidence interval (CI) 1.11-1.84) and all-cause mortality (HR 2.26, 95% CI, 1.86-2.75). After multivariable adjustment, the association of FGF23 with incident CVD was rendered non-significant (HR 1.12, 95% CI 0.86-1.46), whereas the positive association of FGF23 with all-cause mortality was maintained (HR: 1.87, 95% CI: 1.52 - 2.29). Analyses modeling FGF23 quartiles yielded similar findings (multivariable-adjusted HR Q4 vs. Q1 for incident CVD: 1.17, 95% CI: 0.87 - 1.59; for death: 1.87, 95% CI: 1.38 - 2.53).

Conclusion: In our large community-based sample, serum FGF23 shows an independent positive association with all-cause mortality, but not with incident CVD risk.

  • Cardiovascular disease
  • Metabolism
  • Author Disclosures: R. Haring: None. R.S. Vasan: None. H. Wallaschofski: None. L. Sullivan: None. D. Enserro: None.

  • © 2014 by American Heart Association, Inc.
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March 25, 2014, Volume 129, Issue Suppl 1
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    Abstract P349: Association Of Fibroblast Growth Factor 23 With Incident Cardiovascular Disease And All-Cause Mortality In The Framingham Heart Study
    Robin Haring, Ramachandran S Vasan, Henri Wallaschofski, Lisa Sullivan and Danielle Enserro
    Circulation. 2014;129:AP349, originally published March 19, 2014

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    Abstract P349: Association Of Fibroblast Growth Factor 23 With Incident Cardiovascular Disease And All-Cause Mortality In The Framingham Heart Study
    Robin Haring, Ramachandran S Vasan, Henri Wallaschofski, Lisa Sullivan and Danielle Enserro
    Circulation. 2014;129:AP349, originally published March 19, 2014
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