Abstract P317: Serum Soy Isoflavones Are Inversely Associated With Coronary Artery Calcification In A Population-based Sample Of 299 Men In Japan
Objectives: Epidemiological studies in Asia where consumption of soy isoflavones (ISF) are regular and high implicated that isoflavones are protective against coronary heart disease (CHD), especially in post-menopausal women. There is a lack of data on the association of isoflavones with atherosclerosis, especially in men. We aim to determine a cross sectional association of serum ISF with coronary artery calcification (CAC) in men in Japan.
Methods: A population-based sample of 299 men aged 40-49 years in Japan was examined for CAC and other risk factors in 2002-06. Electron-beam CT was used to evaluate CAC. Stored serum samples were analyzed for ISF (genistein and daidzein). We defined serum ISFs as the sum of genistein and daidzein. Presence of CAC was defined as coronary calcium score ≥ 10. Because the distribution of serum ISF is skewed, we evaluated quartile of serum ISF and analyzed the association of ISF with the presence of CAC using a general linear model.
Findings: The median value (interquartile range) of ISF was 517 (195, 1,147) nM/l. Serum ISF had a significant inverse association with CAC in crude analysis. After adjusting for age, LDL-C, smoking, and BMI, each of which had a significant univariate association with CAC, the inverse association of ISF with CAC remained, with littel change in point estimates. After further adjusting for other risk factors as well as serum levels of long-chain n-3 polyunsaturated fatty acids, the inverse association remained.
Conclusions: Serum levels of ISF in Japanese men in Japan had an inverse association of CAC, suggesting that ISF at the levels Japanese in Japan regularly consume have anti-atherogenic properties in men.
Author Disclosures: A. Sekikawa: None. K. Miura: None. A. Vishnu: None. A. Fujiyoshi: None. R.W. Evans: None. T. Kadowaki: None. D. Edmundowicz: None. T. Hisamatsu: None. V. Ahuja: None. H. Maegawa: None. M. Bertolet: None. K. Murata: None. T. Okamura: None. E.J.M. Barinas-Mitchell: None. Y. Nakamura: None. L.H. Kuller: None. H. Ueshima: None.
- © 2014 by American Heart Association, Inc.