Abstract P265: Association of Dietary Fatty Acid Intake with Serum High-density Lipoprotein Particle Concentration
Background: Studies have found that HDL particle (HDL-P) concentration is inversely associated with risk of CVD, independent of HDL cholesterol (HDL-C). Dietary factors (such as fatty acid intake) have been found to affect levels of HDL-C and influence risk of CVD. However, little is known about the associations of dietary fatty acid with serum HDL-P levels.
Hypothesis: We hypothesized that dietary fatty acid associations with HDL-P are independent of HDL-C in men.
Methods: Data were from 463 male participants in the 1996-98 cross-sectional INTERLIPID Study, ages 40-59 years, randomly selected from five populations; four in Japan (n=386) and one in Hawaii (n=77). Fatty acid intake was estimated from the mean of four in-depth 24-hour dietary recalls (% kcal per day). Individuals were excluded due to missing data on HDL-P or HDL-C and use of lipid lowering medication. Serum HDL-P was measured using nuclear magnetic resonance and HDL-C was measured using standard methods. Multiple linear regression models were used to assess the association between dietary fatty acid and each of the lipid measures.
Results: In men, HDL-P and HDL-C were moderately correlated (r = 0.52, p<0.001). In Model 1 (Table), adjusted for age, country, alcohol intake, BMI, diabetes, hypertension, smoking status, and physical activity, most dietary fatty acids were significantly (p<0.05) associated with HDL-P and HDL-C levels. In Model 2, further adjusted for HDL-C, almost all fatty acids maintained a significant association with HDL-P. In contrast, most associations of fatty acids and HDL-C ceased to be significant after adjustment for HDL-P. Total SFA and omega-3 PUFA remained associated with HDL-C.
Conclusion: HDL-P was significantly associated with fatty acid intake, independent of HDL-C. Associations of dietary fatty acid intake and HDL-C level were weaker and generally not independent of HDL-P in men.
Author Disclosures: M. Zaid: None. K. Miura: None. A. Fujiyoshi: None. A. Okayama: None. H. Nakagawa: None. K. Sakata: None. S. Saito: None. N. Okuda: None. K. Yoshita: None. S. Choudhury: None. B. Rodriguez: None. K. Masaki: None. B. Willcox: None. N. Miyagawa: None. J. Stamler: None. H. Ueshima: None.
- © 2014 by American Heart Association, Inc.