Abstract P263: The Associations of Epithelial Sodium Channel Genes with Blood Pressure Changes and Hypertension Incidence: the GenSalt Study
We examined the associations of common variants in ENaC genes with BP changes and hypertension incidence in a longitudinal family study. A total of 2755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eligible for the current study. The average of nine BP measurements obtained using a random-zero sphygmomanometer at the baseline and each of two follow-up visits were used for the current analysis. The associations of 43 tag-SNPs in ENaC genes with BP changes and hypertension incidence were assessed using mixed models to account for the correlations of repeated measures among individuals and within families. A genotype by time interaction term was used to model differences in BP change according to genotype over time. The false discovery rate (FDR) method was used to adjust for multiple testing. During an average of 7.4 years follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and approximately 33% of participants developed hypertension. Multiple variants in ENaC genes were significantly associated with longitudinal changes in SBP after adjustment for multiple testing, including SCNN1A SNP rs11064153 (Pinteraction = 5.8х10-4; FDR-Q = 0.01); SCNN1G SNPs rs4299163 (Pinteraction= 0.011; FDR-Q = 0.05) and rs4401050 (Pinteraction = 0.001; FDR-Q = 0.01); and SCNN1B SNP rs1004749 (Pinteraction = 0.006; FDR-Q = 0.03). Similar but not significant trends were observed for the associations between both rs11064153 and rs4401050 and DBP changes (Pinteraction = 0.024 and 0.005, respectively; FDR-Q = 0.41 and 0.17, respectively) and between rs11604153 and hypertension incidence (P = 0.017; FDR-Q = 0.19). Our findings indicate that ENaC genes may contribute to longitudinal BP changes in the Han Chinese population. Replication of these findings is warranted.
Author Disclosures: T.N. Kelly: None. X. Yang: None. D.C. Rao: None. D. Gu: None. J.E. Hixson: None. T.K. Rice: None. D. Liu: None. L.C. Shimmin: None. J. He: None.
- © 2014 by American Heart Association, Inc.