Abstract P242: Abdominal Adipose Tissue Distribution and Metabolic Syndrome Burden in Adolescents - Penn State Child Cohort (PSCC) Study
Objectives: To investigate the association between abdominal adipose tissue distribution and metabolic syndrome burden in a population-based sample of adolescents.
Methods: We used available data from 400 adolescents who completed the follow up examinations in the PSCC study. We used whole body low-dose dual energy absorptiometry (DXA) to assess and calculate the following abdominal and body fat distribution measures: Android/Gynoid Fat ratio, Android/whole body fat ratio, Gynoid/whole body fat ratio, visceral fat area, and subcutaneous fat area in the abdominal region. . Metabolic syndrome burden was assessed by using continuous metabolic syndrome score (cMetS) - the sum of the age and sex adjusted standardized residual (Z-score) of five established metabolic syndrome components: waist circumference, mean arterial pressure, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides, and HDL cholesterol. Linear regression models were used to data analysis.
Results: The mean age was 16.9 yrs (SD=2.19), with 54% male and 77% white. The average cMets score was 0.04 SD (3.01). The regression coefficients on cMets score per one SD increase in abdominal adipose tissue measures are shown in Table 1. In summary, higher abdominal adipose tissue, especially in the android (visceral) area, of the abdomen is associated with higher cMetS score.
Conclusion: Obesity, especially visceral obesity, is associated with higher metabolic syndrome burden in adolescent population, which may result in increased metabolic syndrome risk in adulthood.
Author Disclosures: D. Liao: None. F. He: None. S. Rodriguez-Colon: None. J. Fernandez-Mendoza: None. A. Vgontzas: None. E.O. Bixler: None.
- © 2014 by American Heart Association, Inc.