Abstract P239: The Effect of BMI on Cardiovascular and Metabolic Syndrome Risk Factors in an Appalachian Pediatric Population
Background: Few studies have determined the effect of BMI on cardiovascular and metabolic syndrome risk factors in a primarily White, rural pediatric population. This study characterized a rural pediatric population by BMI category.
Methods: Data on 11,084 individuals <20 years of age (mean 12.3, SD 5.0) were obtained from the C8 Health Project, a project that collected blood samples and self- or parent/guardian-reported demographics, medical diagnoses, height, and weight in 2005-2006 following a perfluorooctanoic acid (C8) contamination of drinking water in West Virginia and Ohio. Metabolic syndrome was defined as the presence of at least 3 standard criteria for diagnosis in a pediatric population (BMI >97th percentile, triglycerides >110 mg/dL, HDLc <40mg/dL, and fasting blood glucose >110mg/dL). Results were stratified by BMI category (<85% as normal, 85%-95% as overweight, and >95% as obese). Tests for linear trends across BMI categories and correlations with C8 were conducted.
Results: The population was 51% male, 96% White, and 20% reported an average household income <$10,000. Forty percent (n=4406) were overweight or obese. Table 1 presents characteristics by BMI category. Total cholesterol, LDLc, and VLDLc, triglycerides, non-fasting glucose, fasting insulin, white blood cell count, and C-reactive protein increased with BMI percentiles, while HDLc and serum albumin decreased. No association was seen with fasting glucose. Serum creatinine also increased with BMI category. The point prevalence of metabolic syndrome was 4% (n=473). Serum C8 was not correlated with any variables.
Conclusions: An alarming 40% prevalence of overweight and obesity was observed in this rural pediatric population. Because of the increase seen with cardiovascular and metabolic syndrome risk factors as BMI increased, this rural pediatric population may experience earlier onset of associated disease and complications. This warrants further public health involvement to decrease this Appalachian population’s risk.
Author Disclosures: K. Weber: None. A.F.R. Fischl: None. P.J. Murray: None. B. Conway: None.
- © 2014 by American Heart Association, Inc.