Abstract P238: Marijuana Use and Incident Diabetes: Results from the Coronary Artery Risk Development in Young Adults Study
Marijuana use is common in the United States, but the cardiometabolic effects of marijuana use are unclear, specifically the association with incident diabetes. We examined the association between self-reported marijuana use and incident diabetes in the CARDIA Study, including 3,506 men and women aged 18-30 at the time of enrollment (1985-1986). In order to establish antecedent marijuana use, we classified marijuana use at enrollment and at exams 2, 5, and 7 (years later), and then followed individuals free of diabetes at year 7 for incident events. Marijuana use was modeled in three categories: never users (20% of the population), ever-past use (44% of the population), and ever-recent use (36% of the population). From 1992-2011, we observed 396 incident cases of diabetes ascertained at each exam via fasting glucose values (≥126 mg/dL), oral glucose tolerance test results (≥200 mg/dL), percentage of glycated hemoglobin (HbA1c ≥6.5%), or use of diabetes medications. Cox regression was used to estimate hazard ratios (HR) for incident diabetes according to marijuana use category, after adjustment for age, sex, race, smoking status, alcohol consumption, education, study center, body mass index, systolic blood pressure, LDL- and HDL-cholesterol, caloric intake, physical activity, and other illicit drug use. Results from crude analysis suggested decreased risk of incident diabetes for both ever-past (HR=0.81; 95% CI = 0.62 - 1.04) and ever-recent (HR=0.86; 95% CI = 0.66 - 1.13) marijuana use when compared to never users. In the multivariable model, neither ever-past (HR=1.03; 95% CI = 0.78 - 1.36) or ever-recent (HR=0.97; 95% CI = 0.70 - 1.36) marijuana use was associated with incident diabetes when compared to never users. The findings were not materially different after excluding the first three years of follow up. Marijuana use in young adulthood was not associated with incident diabetes in middle age.
Author Disclosures: M.P. Bancks: None. M.J. Pletcher: None. S.G. Kertesz: None. S. Sidney: None. R.S. Jamal: None. P.J. Schreiner: None.
- © 2014 by American Heart Association, Inc.