Abstract P231: Uric Acid Is Associated with Metabolic Syndrome in Children and Adults: The Bogalusa Heart Study
Background: Elevated serum uric acid (UA) is commonly found in subjects with metabolic syndrome (MetS). This study assessed the hypothesis that UA is associated with levels of individual MetS components and the degree of their clustering patterns in different age periods.
Methods: The study sample consisted of 2614 children (1577 whites, 1037 blacks; 1333 males; aged 4-18 years) and 2447 adults (1682 whites, 1765 blacks; 1072 males; aged 19-54 years) examined during 1987-2010. The adverse levels of MetS components, including body mass index (BMI), mean arterial pressure (MAP), triglycerides to HDL cholesterol ratio (TG/HDLC), and homeostasis model assessment of insulin resistance (HOMA), were defined as >75th percentile specific for age, race and sex. Observed/expected (O/E) ratio and intra-class correlation (ICC) were used as a measure of the degree of clustering of categorical and continuous variables, respectively.
Results: UA was significantly positively associated with only BMI in children, and with all four components in adults. Odds ratios of UA associated with MetS were 1.74 in children and 1.92 in adults (p<0.001 for both), adjusted for race, sex and age. Trends in O/E ratios with UA quartiles are shown in the figure below. ICCs of 3- and 4-component clusters increased with increasing UA quartiles in children; however, only BMI-MAP-HOMA cluster showed an increasing trend of ICC in adults.
Conclusions: The results suggest an important role of UA in the development of MetS in pediatric and adult populations. The findings provide further insights into the potential pathophysiological mechanisms of MetS and have implications for identification and treatment of high risk individuals for MetS in early life.
Author Disclosures: D. Sun: None. X. Zhang: None. S. Li: None. C. Fernandez: None. W. Chen: None. S.R. Srinivasan: None. G.S. Berenson: None.
- © 2014 by American Heart Association, Inc.