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Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Information may not be released before then. Failure to honor embargo policies will result in the abstract being withdrawn and barred from presentation.
Poster Abstract PresentationsSession Title: Stroke

Abstract P226: D-Dimer Levels and Risk of Stroke: Findings from the EPICOR Study

Augusto Di Castelnuovo, Claudia Agnoli, Amalia de Curtis, Maria Concetta Giurdanella, Sara Grioni, Amalia Mattiello, Giuseppe Matullo, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello
Circulation. 2014;129:AP226
Augusto Di Castelnuovo
IRCCS - NEUROMED, Pozzilli, Italy
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Claudia Agnoli
Epidemiology and Prevention Unit. Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
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Amalia de Curtis
IRCCS - NEUROMED, Pozzilli, Italy
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Maria Concetta Giurdanella
Cancer Registry ASP, Ragusa, Italy
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Sara Grioni
IRCCS - NEUROMED, Pozzilli, Italy
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Amalia Mattiello
Dipartimento di Medicina Clinica e Chirurgia, Univ of Naples “Federico II”, Napoli, Italy
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Giuseppe Matullo
Dept of Med Sciences, Univ of Torino, Torino, Italy
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Salvatore Panico
Dipartimento di Medicina Clinica e Chirurgia, Univ of Naples “Federico II”, Napoli, Italy
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Carlotta Sacerdote
Human Genetics Foundation (HuGeF), Torino, Italy
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Rosario Tumino
Cancer Registry ASP, Ragusa, Italy
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Giovanni de Gaetano
IRCCS - NEUROMED, Pozzilli, Italy
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Maria Benedetta Donati
IRCCS - NEUROMED, Pozzilli, Italy
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Licia Iacoviello
IRCCS - NEUROMED, Pozzilli, Italy
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Abstract

Background: Elevated D-dimer levels are reportedly associated with higher risk of vascular diseases. We investigated the association of baseline D-dimer levels with stroke events occurred in the European Prospective Investigation into Cancer and Nutrition-Italy cohort.

Methods: Using a nested case-cohort design, a center-stratified random sample of 832 subjects (66% women, age range 35 to 71) was selected as subcohort and compared with 289 strokes in a mean follow-up of 9 years. D-dimer was measured on fresh citrated plasma by an automated latex-enhanced immunoassay (HemosIL-IL, Milan). The hazard ratios and 95% confidence intervals, adjusted by relevant confounders and stratified by center, were estimated by a Cox regression model using Prentice method.

Results: Individuals in the second, third or fourth quartile compared with the lowest quartile of D-dimer had significantly higher risk of stroke (Table). The association was independent from several potential confounders, including C-Reactive protein (Table). It was evident starting from the second quartile (D-dimer >100 ng/ml) and persisted almost unchanged for higher D-dimer levels (Table). No differences were observed in men and women. The increase in risk was essentially the same both for ischemic and hemorrhagic strokes (Table).

Conclusions: Our data provide a clear evidence that elevated levels of D-dimer are potential risk factors for ischemic or hemorrhagic strokes.


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  • Plasminogen activators
  • Stroke
  • Prevention
  • Author Disclosures: A. Di Castelnuovo: None. C. Agnoli: None. A. de Curtis: None. M. Giurdanella: None. S. Grioni: None. A. Mattiello: None. G. Matullo: None. S. Panico: None. C. Sacerdote: None. R. Tumino: None. G. de Gaetano: None. M. Donati: None. L. Iacoviello: None.

  • © 2014 by American Heart Association, Inc.
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March 25, 2014, Volume 129, Issue Suppl 1
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    Abstract P226: D-Dimer Levels and Risk of Stroke: Findings from the EPICOR Study
    Augusto Di Castelnuovo, Claudia Agnoli, Amalia de Curtis, Maria Concetta Giurdanella, Sara Grioni, Amalia Mattiello, Giuseppe Matullo, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Giovanni de Gaetano, Maria Benedetta Donati and Licia Iacoviello
    Circulation. 2014;129:AP226, originally published March 19, 2014

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    Abstract P226: D-Dimer Levels and Risk of Stroke: Findings from the EPICOR Study
    Augusto Di Castelnuovo, Claudia Agnoli, Amalia de Curtis, Maria Concetta Giurdanella, Sara Grioni, Amalia Mattiello, Giuseppe Matullo, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Giovanni de Gaetano, Maria Benedetta Donati and Licia Iacoviello
    Circulation. 2014;129:AP226, originally published March 19, 2014
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