Abstract P081: Increased Hepatic Fat Is Associated With A More Atherogenic Lipoprotein Profile In Adolescents
Introduction: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common liver disease in pediatrics, and it has been estimated to affect more than one third of obese adolescents in the United States. In adolescents with NAFLD, traditional markers of increased cardiovascular risk are commonly reported including elevated triglycerides and reduced HDL-cholesterol levels. Despite the fact that lipoproteins are critically involved in atherogenesis and cardiovascular disease, the independent impact of NAFLD on size and particle concentration of major lipoproteins remains less well described and studies in pediatric population are particularly scarce.
Hypothesis: In the current study, we assessed the hypothesis that in adolescents, high hepatic fat would have a strong association with an atherogenic pattern of lipoprotein particle size and concentration.
Methods: Hispanic-American overweight and obese adolescents (n=50) were recruited from pediatric clinics at Emory Children’s Center and from nearby community centers through flyers and presentations at community events. We evaluated their hepatic fat content by magnetic resonance spectroscopy and measured lipoprotein particles by nuclear magnetic resonance (Liposcience, Raleigh, NC).
Results: Using the 5% hepatic fat to stratify subjects with low (n=13) and high hepatic fat (n=37), adolescents with high hepatic fat have undesirable lipoprotein subclass profiles, including larger VLDL particle size (51.2 ± 1.36 vs. 44.8 ± 1.31 nm, p=0.010), more large VLDL particle numbers (5.75 ± 0.93 vs. 1.32 ± 0.18 nmol/L, p<0.001), and fewer large HDL particles (4.15 ± 0.33 vs. 5.69 ± 0.67 μmol/L, p=0.033). Strong correlations were found between hepatic fat and the number of large VLDL particles (r=0.521, p<0.001), VLDL particle size (r=0.439, p=0.002), and small, dense LDL particle numbers (r=0.291, p=0.040).
Conclusions: The amount of hepatic fat is closely related to the presence of large VLDL particle and small dense LDL, two important predictors of CVD. This suggests that hepatic fat and the associated dyslipidemia have interrelated mechanisms. Further studies with histologic assessment of NAFLD (liver biopsies) will be needed to confirm our findings and to explore causation.
Author Disclosures: R. Jin: None. N. Le: B. Research Grant; Modest; Merck. G. Consultant/Advisory Board; Modest; Liposcience. J. Otvos: A. Employment; Significant; LipoScience. F. Ownership Interest; Significant; LipoScience. M.B. Vos: None.
- © 2014 by American Heart Association, Inc.