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Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Information may not be released before then. Failure to honor embargo policies will result in the abstract being withdrawn and barred from presentation.
Moderated Poster Abstract PresentationsSession Title: Nutrition

Abstract MP61: Dietary Fiber Intake and Mortality Among Myocardial Infarction Survivors

Shanshan Li, Alan Flint, Jennifer Pai, John Forman, Frank Hu, Walter Willett, Kathryn Rexrode, Kenneth Mukamal, Eric Rimm
Circulation. 2014;129:AMP61
Shanshan Li
Harvard Sch of Public Health, Boston, MA
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Alan Flint
Harvard Sch of Public Health, Boston, MA
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Jennifer Pai
Harvard Sch of Public Health, Boston, MA
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John Forman
Brigham and Women’s Hosp and Harvard Med Sch, Boston, MA
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Frank Hu
Harvard Sch of Public Health, Boston, MA
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Walter Willett
Harvard Sch of Public Health, Boston, MA
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Kathryn Rexrode
Brigham and Women’s Hosp and Harvard Med Sch, Boston, MA
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Kenneth Mukamal
Beth Israel Deaconess Med Cntr, Boston, MA
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Eric Rimm
Harvard Sch of Public Health, Boston, MA
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Abstract

Background: Dietary fiber is associated with lower risk of coronary heart disease in healthy populations. It is unclear whether higher consumption of dietary fiber after myocardial infarction (MI) is associated with lower mortality.

Objective: To evaluate the associations of dietary fiber post-MI and changes from pre- to post- with all-cause and cardiovascular mortality.

Design: The Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS) are two large prospective cohort studies of US women and men with repeated dietary measurements. We included 2,258 women and 1,840 men who were free of cardiovascular disease, stroke or cancer at enrollment, survived a first MI during follow up, were free of stroke at the time of initial MI onset, and provided both pre-MI and at least one post-MI food frequency questionnaire. We evaluated the associations of dietary fiber post-MI and changes from pre- to post- with all-cause and cardiovascular mortality using Cox proportional hazards models, adjusting for medication use, medical history, and lifestyles factors.

Results: Higher post-MI fiber intake was significantly associated with lower all-cause mortality (Comparing extreme quintiles, pooled hazard ratio (HR) = 0.75, 95%CI: 0.58-0.97). Greater intake of cereal fiber was more strongly associated with all-cause mortality (Pooled HR=0.73, 95%CI: 0.58-0.91) than were other sources of dietary fiber. Increased fiber intake from pre- to post- was significantly associated with lower all-cause mortality (Pooled HR=0.69, 95%CI: 0.55-0.87).

Conclusions: In this prospective study of MI survivors, greater post-MI intake of dietary fiber, especially cereal fiber, was inversely associated with all-cause mortality. In addition, increasing consumption of fiber from pre- to post-MI periods was significantly associated with lower all-cause and cardiovascular mortality.

  • Myocardial infarction
  • Prognosis
  • Nutrition
  • Author Disclosures: S. Li: None. A. Flint: None. J. Pai: None. J. Forman: None. F. Hu: None. W. Willett: None. K. Rexrode: None. K. Mukamal: None. E. Rimm: None.

  • © 2014 by American Heart Association, Inc.
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    Abstract MP61: Dietary Fiber Intake and Mortality Among Myocardial Infarction Survivors
    Shanshan Li, Alan Flint, Jennifer Pai, John Forman, Frank Hu, Walter Willett, Kathryn Rexrode, Kenneth Mukamal and Eric Rimm
    Circulation. 2014;129:AMP61, originally published March 19, 2014

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    Abstract MP61: Dietary Fiber Intake and Mortality Among Myocardial Infarction Survivors
    Shanshan Li, Alan Flint, Jennifer Pai, John Forman, Frank Hu, Walter Willett, Kathryn Rexrode, Kenneth Mukamal and Eric Rimm
    Circulation. 2014;129:AMP61, originally published March 19, 2014
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