Abstract MP08: Bundle Branch Blocks and Risk of Mortality in the Atherosclerosis Risk in Communities Study: Gender and Racial Differences
Introduction: Gender and racial differences in the association between different patterns of bundle branch block (BBB) and mortality in the general population are not well established.
Methods: We used Cox proportional hazard models to evaluate the risk of all-cause mortality associated with left BBB (LBBB) and right BBB (RBBB). The study group, 15,316 participants from the Atherosclerosis Risk in Communities (ARIC) study was stratified by gender and race. We excluded the participants with other BBBs or QRS duration ≥120 ms not classified as complete RBBB or LBBB.
Results: At baseline in 1987-89, mean age was 54 years, 55.3% were women, and 26.8% blacks. There were 88 LBBB and 202 RBBB. During a mean follow up of 18 years, 3,347 deaths occurred. Compared to No-BBB, LBBB was strongly associated with increased mortality in all subgroups by gender and race (Table). However, RBBB was not significantly associated with all-cause mortality in any of the subgroups in the multivariable adjusted models.
Conclusions: Prevalent LBBB, but not RBBB, is a predictor of all-cause mortality in women and men as well as in blacks and whites. These findings may help in selecting patients who could benefit from further diagnostic evaluation for possible therapeutic and preventive intervention.
Author Disclosures: Z. Zhang: None. P.M. Rautaharju: None. R.J. Prineas: None. L. Loehr: None. W. Rosamond: None. E.Z. Soliman: None.
- © 2014 by American Heart Association, Inc.