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AHA/ACC Prevention Guideline
Open Access

2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk

A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Robert H. Eckel, John M. Jakicic, Jamy D. Ard, Janet M. de Jesus, Nancy Houston Miller, Van S. Hubbard, I-Min Lee, Alice H. Lichtenstein, Catherine M. Loria, Barbara E. Millen, Cathy A. Nonas, Frank M. Sacks, Sidney C. Smith, Laura P. Svetkey, Thomas A. Wadden, Susan Z. Yanovski
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https://doi.org/10.1161/01.cir.0000437740.48606.d1
Circulation. 2014;129:S76-S99
Originally published November 12, 2013
Robert H. Eckel
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John M. Jakicic
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Jamy D. Ard
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Janet M. de Jesus
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Nancy Houston Miller
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Van S. Hubbard
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I-Min Lee
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Alice H. Lichtenstein
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Catherine M. Loria
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Barbara E. Millen
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Cathy A. Nonas
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Frank M. Sacks
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Sidney C. Smith
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Laura P. Svetkey
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Thomas A. Wadden
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Susan Z. Yanovski
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This article has corrections. Please see:

  • Correction - June 24, 2014
  • Correction - January 27, 2015
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  • Article
    • Table of Contents
    • Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk
    • 2. Lifestyle Management Recommendations
    • 3. CQ1—Dietary Patterns and Macronutrients: BP and Lipids
    • 4. CQ2—Sodium and Potassium: BP and CVD Outcomes
    • 5. CQ3—Physical Activity: Lipids and BP
    • 6. Gaps in Evidence and Future Research Needs
    • Presidents and Staff
    • Appendix
    • Appendix
    • Appendix
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  • AHA Scientific Statements
  • cardiovascular disease
  • blood cholesterol
  • blood pressure
  • nutrition
  • dietary patterns
  • dietary fats
  • dietary sodium
  • physical activity

Table of Contents

Preamble and Transition to ACC/AHA Guidelines to

  • Reduce Cardiovascular Risk S77

    • 1.1. Scope of Guideline S78

    • 1.2. Methodology and Evidence Review S78

      • 1.2.1. Scope of the Evidence Review S78

      • 1.2.2. CQ-Based Approach S81

    • 1.3. Organization of Work Group S81

    • 1.4. Document Reviews and Approval S81

  • 2. Lifestyle Management Recommendations S83

  • 3. CQ1—Dietary Patterns and Macronutrients: BP and Lipids S83

    • 3.1. Introduction/Rationale S83

    • 3.2. Selection of Inclusion/Exclusion Criteria S83

    • 3.3. Literature Search Yield S83

      • 3.3.1. Dietary Pattern/Macronutrient Composition Evidence S83

    • 3.4. CQ1 Evidence Statements S83

      • 3.4.1. Dietary Patterns S83

        • 3.4.1.1. MED Pattern S83

        • 3.4.1.2. DASH Dietary Pattern S83

        • 3.4.1.3. DASH Variations S84

      • 3.4.2. Dietary Fat and Cholesterol S84

    • 3.5. Diet Recommendations for LDL-C Lowering S84

  • 4. CQ2—Sodium and Potassium: BP and CVD Outcomes S85

    • 4.1. Introduction and Rationale S85

    • 4.2. Selection of Inclusion/Exclusion Criteria S86

    • 4.3. Literature Search Yield S87

    • 4.4. CQ2 Evidence Statements S87

      • 4.4.1. Sodium and BP S87

    • 4.5. Diet Recommendations for BP Lowering S87

  • 5. CQ3—Physical Activity: Lipids and BP S89

    • 5.1. Introduction/Rationale S89

    • 5.2. Selection of Inclusion/Exclusion Criteria S89

    • 5.3. Literature Search Yield S90

    • 5.4. CQ3 Evidence Statements S90

      • 5.4.1. Physical Activity and Lipids S90

      • 5.4.2. Physical Activity and BP S90

        • 5.4.2.1. Aerobic Exercise Training and BP S90

        • 5.4.2.2. Resistance Exercise Training and BP S90

        • 5.4.2.3. Combination of Aerobic and Resistance Exercise Training and BP S91

    • 5.5. Physical Activity Recommendations S91

    • 5.6. Heart-Healthy Nutrition and Physical Activity Behaviors S91

  • 6. Gaps in Evidence and Future Research Needs S91

    • 6.1. Diet S91

    • 6.2. Physical Activity S92

  • References S93

  • Appendix 1. Author Relationships With Industry and Other Entities (Relevant) S96

  • Appendix 2. Expert Reviewer Relationships With Industry and Other Entities S99

  • Appendix 3. Abbreviations S99

Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk

The goals of the American College of Cardiology (ACC) and the American Heart Association (AHA) are to prevent cardiovascular diseases (CVDs); improve the management of people who have these diseases through professional education and research; and develop guidelines, standards, and policies that promote optimal patient care and cardiovascular health. Toward these objectives, the ACC and AHA have collaborated with the National Heart, Lung, and Blood Institute (NHLBI) and stakeholder and professional organizations to develop clinical practice guidelines for assessment of cardiovascular risk, lifestyle modifications to reduce cardiovascular risk, management of blood cholesterol in adults, and management of overweight and obesity in adults.

In 2008, the NHLBI initiated these guidelines by sponsoring rigorous systematic evidence reviews for each topic by expert panels convened to develop critical questions (CQs), interpret the evidence, and craft recommendations. In response to the 2011 report from the Institute of Medicine on the development of trustworthy clinical guidelines,1 the NHLBI Advisory Council recommended that the NHLBI focus specifically on reviewing the highest-quality evidence and partner with other organizations to develop recommendations.2,3 Accordingly, in June 2013 the NHLBI initiated collaboration with the ACC and AHA to work with other organizations to complete and publish the 4 guidelines noted above and make them available to the widest possible constituency. Recognizing that the Expert Panels/Work Groups did not consider evidence beyond 2011 (except as specified in the methodology), the ACC, AHA, and collaborating societies plan to begin updating these guidelines starting in 2014.

The joint ACC/AHA Task Force on Practice Guidelines (Task Force) appointed a subcommittee to shepherd this transition, communicate the rationale and expectations to the writing panels and partnering organizations, and expeditiously publish the documents. The ACC/AHA and partner organizations recruited a limited number of expert reviewers for fiduciary examination of content, recognizing that each document had undergone extensive peer review by representatives of the NHLBI Advisory Council, key federal agencies, and scientific experts. Each writing panel responded to comments from these reviewers. Clarifications were incorporated where appropriate, but there were no substantive changes because the bulk of the content was undisputed.

Although the Task Force led the final development of these prevention guidelines, they differ from other ACC/AHA guidelines. First, as opposed to an extensive compendium of clinical information, these documents are significantly more limited in scope and focus on selected CQs on each topic, based on the highest-quality evidence available. Recommendations were derived from randomized trials, meta-analyses, and observational studies evaluated for quality and were not formulated when sufficient evidence was not available. Second, the text accompanying each recommendation is succinct, summarizing the evidence for each question. The Full Panel/Work Group Reports include more detailed information about the evidence statements (ESs) that serve as the basis for recommendations. Third, the format of the recommendations differs from other ACC/AHA guidelines. Each recommendation has been mapped from the NHLBI grading format to the ACC/AHA Classification of Recommendation/Level of Evidence (COR/LOE) construct (Table 1) and is expressed in both formats. Because of the inherent differences in grading systems and the clinical questions driving the recommendations, alignment between the NHLBI and ACC/AHA formats is in some cases imperfect. Explanations of these variations are noted in the recommendation tables, where applicable.

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Table 1.

Applying Classification of Recommendation and Level of Evidence

In consultation with NHLBI, the policies adopted by the writing panels to manage relationships of authors with industry and other entities (RWI) are outlined in the methods section of each panel report. These policies were in effect when this effort began in 2008 and throughout the writing process and voting on recommendations, until the process was transferred to ACC/AHA in 2013. In the interest of transparency, the ACC/AHA requested that panel authors resubmit RWI disclosures as of July 2013. Relationships relevant to this guideline are disclosed in Appendix 1. None of the ACC/AHA expert reviewers had relevant RWI (Appendix 2). See Appendix 3 for a list of abbreviations used in the guideline.

Systematic evidence reports and accompanying summary tables were developed by the expert panels and NHLBI. The guideline was reviewed by the ACC/AHA Task Force and approved by the ACC Board of Trustees and the AHA Science Advisory and Coordinating Committee. In addition, ACC/AHA sought endorsement from other stakeholders, including professional organizations. It is the hope of the writing panels, stakeholders, professional organizations, NHLBI, and Task Force that the guidelines will garner the widest possible readership for the benefit of patients, providers, and the public health.

These guidelines are meant to define practices that meet the needs of patients in most circumstances and are not a replacement for clinical judgment. The ultimate decision about care of a particular patient must be made by the healthcare provider and patient in light of the circumstances presented by that patient. As a result, situations might arise in which deviations from these guidelines may be appropriate. These considerations notwithstanding, in caring for most patients, clinicians can employ the recommendations confidently to reduce the risks of atherosclerotic CVD events.

See Tables 2 and 3 for an explanation of the NHLBI recommendation grading methodology.

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Table 2.

NHLBI Grading of the Strength of Recommendations

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Table 3

NHLBI Quality Rating of the Strength of Evidence

1.1. Scope of Guideline

See Table 4 for the Lifestyle Expert Work Group's CQs.

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Table 4.

Critical Questions

A healthy lifestyle is important in the prevention of CVD, the leading cause of morbidity and mortality worldwide. The intent of the Lifestyle Work Group (Work Group) was to evaluate evidence that particular dietary patterns, nutrient intake, and levels and types of physical activity can play a major role in CVD prevention and treatment through effects on modifiable CVD risk factors (ie, blood pressure [BP] and lipids). These ESs and recommendations may be used as appropriate in the management of hypercholesterolemia and hypertension. The target audience of the report is primary care providers.

This guideline is based on the Full Work Group Report, which is provided as an online-only data supplement to the guideline. The Full Work Group Report supplement contains background and additional material related to content, methodology, evidence synthesis, rationale, and references and is supported by the NHLBI Systematic Evidence Review, which can be found at http://www.nhlbi.nih.gov/guidelines/cvd_adult/lifestyle/.

Diet and physical activity interventions of interest to the Work Group that were not included in this report because of time and resource limitations were the following: calcium, magnesium, alcohol, cardiorespiratory fitness, single behavioral intervention or multicomponent lifestyle interventions, the addition of lifestyle intervention to pharmacotherapy, and smoking. Outcomes of interest not covered in this evidence review were the following risk factors: diabetes mellitus (diabetes)- and obesity-related measurements, incident diabetes metabolic syndrome, high-sensitivity C-reactive protein, and other inflammatory markers. The Work Group was interested in reviewing the evidence for CVD outcomes in all of the CQs; however, the evidence for mortality and CVD outcomes was reviewed only in CQ2.

1.2. Methodology and Evidence Review

1.2.1. Scope of the Evidence Review

To formulate the nutrition recommendations, the Work Group used randomized controlled trials (RCTs), observational studies, meta-analyses, and systematic reviews of studies carried out in adults (≥18 years of age) with or without established coronary heart disease/CVD and with or without risk factors for coronary heart disease/CVD, who were of normal weight, overweight, or obese. The evidence review date range was 1998 to 2009. To capture historical data or more recent evidence, date ranges were changed for subquestions in some instances. The evidence date ranges are described clearly in each CQ section. The Work Group assessed the impact of both dietary patterns and macronutrient composition on plasma low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides and on systolic BP and diastolic BP over a minimum RCT intervention period of 1 month in studies performed in any geographic location and research setting.

Overall, the Work Group emphasized dietary patterns rather than individual dietary components. Patterns were characterized by habitual or prescribed combinations of daily food intake. Dietary patterns offer the opportunity to characterize the overall composition and quality of the eating behaviors of a population (eg, Mediterranean-style dietary [MED] pattern). Eating patterns consist of various combinations of foods that may differ in macronutrient, vitamin, and mineral compositions. The macronutrients saturated, trans, monounsaturated, and polyunsaturated fatty acids are particularly relevant for their effects on plasma lipids and lipoproteins. Dietary sodium and potassium are particularly relevant for their effects on BP. Epidemiological research has examined the dietary patterns of populations and identified associations between various patterns and CVD risk factors and outcomes. Intervention studies have tested a priori hypotheses involving prescribed dietary patterns specifically formulated on the basis of these data (eg, Dietary Approaches to Stop Hypertension [DASH] or MED patterns). Population-based prospective cohort studies and RCTs suggest that there are healthier overall dietary patterns (foods and/or their constituent macronutrient, vitamin, and mineral combinations) that are associated with lower risk of chronic diseases, including CVD and risk factors such as type 2 diabetes and hypertension. We reviewed data exclusively on dietary intake rather than nutritional supplements provided in pharmaceutical preparations (eg, potassium pills), because nutritional supplements may not have similar effects and are not considered “lifestyle” interventions.

The Work Group focused on CVD risk factors to provide a free-standing Lifestyle document and to inform the Blood Cholesterol guideline4 and the hypertension panel. It also recognized that RCTs examining the effects on hard outcomes (myocardial infarction, stroke, heart failure, and CVD-related death) are difficult if not impossible to conduct for several reasons (eg, long-term adherence to dietary changes). However, the Work Group also supplemented this evidence on risk factors with observational data on hard outcomes for sodium. The Work Group prioritized topics for the evidence review and was unable to review the evidence on hard outcomes for dietary patterns or physical activity.

For physical activity, substantial epidemiological evidence links higher levels of aerobic physical activity to lower rates of CVD and other chronic diseases, such as type 2 diabetes. Evidence indicates a dose-dependent inverse relationship between levels of physical activity and rates of CVD. The proposed mechanisms mediating the relationship between physical activity and decreased CVD rates include beneficial effects on lipids, lipoproteins, BP, and type 2 diabetes. The search for evidence related to physical activity and CVD included only systematic reviews and meta-analyses of RCTs or individual controlled clinical trials in adults (≥18 years of age) that were published from 2001 to 2011. For this CQ, the intervention was defined as physical activity interventions of any type.

Weight loss and maintenance are crucial for prevention and control of CVD risk factors. The Obesity Expert Panel simultaneously performed a systematic review of the evidence for weight management and CVD risk factors and outcomes.5 The primary intent of the Work Group's systematic review was to focus on the effects of diet and physical activity on CVD risk factors independent of effects on weight. Therefore, studies in which the primary outcome was weight loss or in which treatment was associated with >3% change in weight were excluded from the present review. However, the Work Group expects that recommendations from both evidence reviews will apply to many patients.

Because of limited resources and time, the Work Group could not review every study pertaining to lifestyle and CVD risk factors and outcomes. Priority was given to strong study design and a contemporaneous timeframe (1998 to 2009). However, there were instances in which the evidence review was extended beyond that timeframe. Landmark evidence on the effect of fatty acids on lipids was included back to 1990. The sodium evidence review included evidence through April 2012, and the physical activity meta-analysis review was extended to May 2011. Given the expertise of Work Group members and their familiarity with the literature in this field, the Work Group is confident that a broader review would not substantially change our conclusions or recommendations.

The results of the Work Group systematic review are the 10 lifestyle recommendations (8 dietary and 2 physical activity recommendations) (Table 5). Because the Work Group was convened to inform the development of clinical guidelines, and because most data meeting our criteria for review were derived from studies of high-risk populations, these recommendations are directed at patients with CVD risk factors (ie, abnormal lipids and/or prehypertension and hypertension). The majority of adults in the United States currently have ≥1 of these risk factors (33.5% with elevated LDL-C; 27.3%, hypertension; 31%, prehypertension; and 11.3%, diabetes), with risk factors increasing with age.6 The Work Group encourages heart-healthy nutrition and physical activity behaviors for all adults (Section 5.6) (Table 17).

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Table 5.

Summary of Recommendations for Lifestyle Management

For both BP and lipids, most studies of diet and/or physical activity exclude people taking antihypertensive or lipid-lowering medications. Although there is no direct evidence, it is reasonable to expect that the beneficial effects of these lifestyle recommendations apply to those taking such medications and that following these recommendations can potentially lead to better BP and lipid control in those taking medications and/or reduced medication needs. The recommendations apply to adults <80 years of age with and without CVD.

1.2.2. CQ-Based Approach

The Work Group developed an initial set of questions based on their expertise and a brief literature review to identify topics of the greatest relevance and impact for the target audience of the guideline: primary care providers Because of time and resource limitations, the Work Group prioritized the 3 CQs in Table 4.

The body of this report is organized by CQ. For each CQ:

  • The rationale for its selection is provided, and methods are described.

  • The ESs are presented, which include a rating for quality, a rationale that supports each item of evidence, and a statement. A detailed description of methods is provided in the NHLBI Lifestyle Systematic Evidence Review Report (http://www.nhlbi.nih.gov/guidelines/cvd_adult/lifestyle/). The Full Work Group Report supplement presents documentation for search strategies and results from the search of the published literature.

  • Recommendations include recommendation strength, accompanied by a summary of how the recommendation derives from the evidence and a discussion of issues considered by the Work Group in formulating the recommendation. The ACC/AHA COR/LOE ratings have also been added.

The ESs and recommendations are presented by CQ and grouped by topic:

  • CQ1 presents evidence on dietary patterns and macronutrients and their effect on BP and lipids. The dietary recommendations for LDL-C lowering are described at the end of CQ1.

  • CQ2 presents the evidence on the effect of dietary sodium and potassium intake on BP and CVD outcomes. The dietary recommendations for BP lowering are located at the end of CQ2.

  • Finally, CQ3 presents evidence on the effect of physical activity on lipids and BP and physical activity recommendations for BP and lipid lowering. The physical activity recommendations for BP and lipid lowering are located at the end of CQ3.

It should be recognized that formulating recommendations derived from evidence reviews in response to CQs has some advantages as well as limitations. Because of its desire to adhere to the highest quality of evidence, the Work Group was restricted to using evidence that met inclusion/exclusion and quality criteria established by the Work Group in partnership with the methodologists. When the phrase “there is insufficient evidence” is used, the reader must distinguish between “insufficient” evidence where no studies meeting inclusion/exclusion and quality criteria were found to answer a CQ and “insufficient” evidence where RCTs or observational studies were conducted but the available data do not provide sufficient information to formulate a recommendation. This perspective is important because clinicians could see fewer recommendations derived from expert opinion. Given this perspective, the clinical and research community can identify research questions that need to be answered in the future to refine recommendations when updates to the guideline are written (Section 6).

1.3. Organization of Work Group

The Work Group was composed of 12 members and 4 ex-officio members, including physicians and experts in BP, blood cholesterol, obesity, and lifestyle management. The authors came from the primary care, nursing, pharmacology, nutrition, exercise, behavioral science, and epidemiology disciplines and also included senior scientific staff from NHLBI and the National Institutes of Health.

1.4. Document Reviews and Approval

A formal peer review process initially was completed under the auspices of the NHLBI and included 6 expert reviewers and representatives of federal agencies. This document was also reviewed by 4 expert reviewers nominated by the ACC and the AHA when the management of the guideline transitioned to the ACC/AHA. The ACC and AHA reviewers’ RWI information is published in this document (Appendix 2).

This document was approved for publication by the governing bodies of the ACC and AHA and endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, American Pharmacists Association, American Society for Nutrition, American Society for Preventive Cardiology, American Society of Hypertension, Association of Black Cardiologists, National Lipid Association, Preventive Cardiovascular Nurses Association, and WomenHeart: The National Coalition for Women With Heart Disease.

2. Lifestyle Management Recommendations

See Table 5 for the Summary of Lifestyle Recommendations.

3. CQ1—Dietary Patterns and Macronutrients: BP and Lipids

See Table 6 for the CQ for BP and lipids with dietary patterns and macronutrients.

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Table 6.

CQ for Dietary Patterns and Macronutrients: BP and Lipids

3.1. Introduction/Rationale

The importance of nutrition in modifying the risk of CVD has been repeatedly emphasized.7–11 Historically, the role of dietary components has been the predominant focus; however, foods are typically consumed in combinations rather than individually. Over the past few years, increasing attention has been given to dietary patterns and their relationship to health outcomes such as CVD.12–20

In intervention studies, specific dietary patterns of defined macronutrient composition are identified on the basis of expert evidence and a priori hypothesis (eg, the DASH or MED patterns) and then are evaluated in RCTs. In observational studies, associations between intake and risk factors are assessed. Because of resource limitations, CVD morbidity and mortality outcomes were not included in the evidence review for this question. The charge of the Work Group was to inform the treatment of lipids and BP; therefore, those risk factors were the outcomes of focus.

3.2. Selection of Inclusion/Exclusion Criteria

Work Group members developed eligibility criteria based on a Population, Intervention, Comparator, Outcomes, Timing, and Setting (PICOTS) approach for screening potential studies for inclusion in this evidence review. The details of the PICOTS approach for CQ1 and Literature Search Yield, including summary tables, are available in the Full Work Group Report supplement.

3.3. Literature Search Yield

3.3.1. Dietary Pattern/Macronutrient Composition Evidence

In all, 17 studies (28 articles) satisfied the final inclusion criteria and were rated to be of good or fair quality.21–48

The Dietary Pattern Summary Tables (Tables B–1 through B–8) are available in the Full Work Group Report supplement. The tables present summary data on the included studies organized by dietary pattern/macronutrient composition or subpopulations of interest, defined by age, sex, race, or comorbid condition. Some studies appear in more than 1 summary table because they address more than 1 corresponding macronutrient composition or dietary pattern comparison.

3.4. CQ1 Evidence Statements

3.4.1. Dietary Patterns

3.4.1.1. MED Pattern

MED pattern description (Table 7): There was no uniform definition of the MED diet in the RCTs and cohort studies examined. The most common features of diets in these studies were that they were higher in fruits (particularly fresh), vegetables (emphasizing root and green varieties), whole grains (cereals, breads, rice, or pasta), and fatty fish (rich in omega-3 fatty acids); were lower in red meat (emphasizing lean meats); substituted lower-fat or fat-free dairy products for higher-fat dairy foods; and used oils (olive or canola), nuts (walnuts, almonds, or hazelnuts), or margarines blended with rapeseed or flaxseed oils in lieu of butter and other fats. The MED patterns examined tended to be moderate in total fat (32% to 35% of total calories), relatively low in saturated fat (9% to 10% of total calories), high in fiber (27 to 37 g/d), and high in polyunsaturated fatty acids (particularly omega-3s).

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Table 7.

ESs for BP and Lipids With the MED Pattern

3.4.1.2. DASH Dietary Pattern

DASH dietary pattern description (Table 8): The DASH dietary pattern is high in vegetables, fruits, low-fat dairy products, whole grains, poultry, fish, and nuts and is low in sweets, sugar-sweetened beverages, and red meats. The DASH dietary pattern is low in saturated fat, total fat, and cholesterol. It is rich in potassium, magnesium, and calcium, as well as protein and fiber.

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Table 8.

ESs for BP and Lipids With the DASH Pattern

3.4.1.3. DASH Variations

DASH variations description (Table 9): In OmniHeart (Optimal Macronutrient Intake Trial for Heart Health), 2 variations of the DASH dietary pattern were compared with DASH: one that replaced 10% of total daily energy from carbohydrate with protein, and another that replaced the same amount of carbohydrate with unsaturated fat. These patterns were studied in an adequately powered crossover trial of 164 adults in which the participants were given all of their daily food.

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Table 9.

ESs for DASH Variations/Glycemic Index/Load Dietary Approaches

3.4.2. Dietary Fat and Cholesterol

See Table 10 for ESs for saturated fat, trans fat, and dietary cholesterol.

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Table 10.

ESs for Dietary Fat and Cholesterol

3.5. Diet Recommendations for LDL-C Lowering*

The following diet recommendations for LDL-C lowering are based on the ESs from CQ1 on dietary patterns and fatty acids. Diet recommendations for BP lowering are based on CQ1 and CQ2 and are located after the CQ2 ESs. The physical activity and lipids ESs and recommendations are located in CQ3.

  1. Advise adults who would benefit from LDL-C lowering to:

    • • Consume a dietary pattern that emphasizes intake of vegetables, fruits, and whole grains; includes low-fat dairy products, poultry, fish, legumes, nontropical vegetable oils, and nuts; and limits intake of sweets, sugar-sweetened beverages, and red meats.

      • ○ Adapt this dietary pattern to appropriate calorie requirements, personal and cultural food preferences, and nutrition therapy for other medical conditions (including diabetes).

      • ○ Achieve this pattern by following plans such as the DASH dietary pattern, the US Department of Agriculture (USDA) Food Pattern, or the AHA Diet.

NHLBI Grade: A (Strong); ACC/AHA COR: I, LOE: A

Rationale: This recommendation is based largely on studies of the DASH dietary pattern (DASH and DASH-Sodium), which provided the highest-quality evidence for a dietary pattern causing improvements in BP and lipid profiles (Tables 8 and 9). The LDL-C–lowering effect has been demonstrated in men and women, African Americans and non–African Americans, and in adults of all ages (Table 8, ES6). The evidence suggests that the effects of the recommended dietary pattern persist as long as the pattern is consumed.

The caloric (energy) intake should be appropriate for the individual (eg, restricted for those attempting weight loss). Patients should also be encouraged to adapt the recommended dietary pattern to their personal and cultural preferences. Materials are available to assist patients in achieving the recommended dietary pattern at different calorie levels (Table 9). The 2010 US Department of Health and Human Services Dietary Guidelines for Americans recommend the USDA Food Pattern and the DASH dietary pattern.49 Overall, the recommended dietary pattern is consistent with the AHA Diet50 and the USDA Food Pattern.49 The USDA Food Pattern offers lacto-ovo vegetarian and vegan adaptations. Therefore, this recommendation is consistent with other national guidelines. Clinicians should be familiar with the recommendations, advise their patients to adopt them, and provide easy access to information (Table 11). Dietary planning and nutritional counseling are often facilitated by referral to a nutrition professional.

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Table 11.

Resources and Information for Dietary Planning

  • 2. Advise adults who would benefit from LDL-C lowering to:

    • • Aim for a dietary pattern that achieves 5% to 6% of calories from saturated fat.

NHLBI Grade: A (strong); ACC/AHA COR: I, LOE: A

Rationale: As described in Table 10, ES11 there is strong evidence that reductions in LDL-C were achieved when dietary patterns were followed in which saturated fat intake was reduced from 14% to 15% of calories to 5% to 6%. As previously noted, these studies did not isolate the effect of saturated fat on LDL-C lowering. Intake of saturated fat has decreased in the United States over the past few decades and is currently estimated at 11% of energy in the US population ≥2 years of age.51 However, this level of saturated fat intake is higher than that tested in the DASH and DELTA (Dietary Effects on Lipoproteins and Thrombogenic Activity) trials (5% to 6%) and is not consistent with consuming a diet rich in vegetables, fruits, low-fat dairy products, whole grains, poultry, fish, legumes and nuts, and vegetable oils and limited in sweets, sugar-sweetened beverages, and red meat. Given the current average intake of saturated fat at 11% of calories, it would be beneficial for those who would benefit from LDL-C lowering to decrease saturated fat intake to 5% to 6% of calories.

  • 3. Advise adults who would benefit from LDL-C lowering to:

    • • Reduce percentage of calories from saturated fat.

NHLBI Grade: A (strong); ACC/AHA COR: I, LOE: A

Rationale: Reducing saturated fat intake lowers both LDL-C and HDL-C. Because the absolute effect tends to be greater for LDL-C than HDL-C, reducing saturated fat intake has a beneficial effect on the lipid profile. Given that reducing saturated fat intake lowers LDL-C regardless of whether the saturated fat is replaced by carbohydrate, monounsaturated fatty acids, or polyunsaturated fatty acids, the Work Group does not specify which of these 3 macronutrients should be substituted in place of saturated fat. However, favorable effects on lipid profiles are greater when saturated fat is replaced by polyunsaturated fatty acids, followed by monounsaturated fatty acids, and then carbohydrates. It is important to note that there are various types and degrees of refinement of carbohydrates. Substitution of saturated fat with whole grains is preferable to refined carbohydrates. For American adults who eat more saturated fat than the current average, some reduction is warranted, and adhering to a “heart-healthy” dietary pattern from dietary recommendation No. 1 for LDL-C lowering will likely result in a reduction of saturated fat.

  • 4. Advise adults who would benefit from LDL-C lowering to:

    • • Reduce percentage of calories from trans fat.

NHLBI Grade: A (strong); ACC/AHA COR: I, LOE: A

Rationale: Reducing intake of trans fatty acids lowers LDL-C, with little or no effect on HDL-C or triglycerides levels. The direction of the relationship between trans fatty acids and LDL-C is consistent, regardless of whether the trans fatty acids are replaced by carbohydrates, monounsaturated fatty acids, or polyunsaturated fatty acids. Using 2003 to 2006 NHANES (National Health and Nutrition Examination Survey) data, intake of trans fat from partially hydrogenated oils was estimated at a mean of 1.3 g/d to 1.6 g/d among the US population ≥2 years of age.52 Although the intake level appears low, certain subgroups within the US population may still be consuming relatively high levels of trans fatty acids. For this reason, the Work Group recommends that emphasis continue to be placed on the reduction of trans fat in the diet. Even if intake of trans fat from partially hydrogenated oils decreases, naturally occurring trans fatty acids in the form of ruminant fat from meat and dairy products may still be present in small amounts in the US diet. Adhering to the recommendation to reduce dietary sources of saturated fat (meat and dairy fat) will result in additional reductions in trans fat intake.

4. CQ2—Sodium and Potassium: BP and CVD Outcomes

See Table 12 for the CQ on BP and CVD outcomes with sodium and potassium.

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Table 12.

CQ for Sodium and Potassium: BP and CVD Outcomes

4.1. Introduction and Rationale

Vitamins and minerals typically are consumed in foods. However, it is sometimes possible to isolate the effect of individual minerals to determine the effects on health outcomes. Therefore, the Work Group decided that a systematic review was warranted to determine the individual effects of the minerals sodium and potassium, which are associated with CVD risk factors and outcomes. Other minerals, such as calcium and magnesium, were also considered but were not included in the systematic review because their consumption is limited to relatively few specific foods or food groups (eg, calcium and dairy products); furthermore, it was unlikely that a recommendation to increase or decrease consumption of the mineral rather than the food could be implemented.

In contrast, sodium was reviewed as a single nutrient because little sodium is found naturally in food, and it is added to foods primarily during preparation, at preservation, and/or at the time of consumption. Therefore, it is theoretically possible to alter sodium intake without altering intake of specific foods or overall dietary pattern. In addition, potassium was reviewed as a single nutrient because it has been hypothesized that dietary potassium intake may lower BP independent of other nutrients or foods. In addition, the effect of sodium on BP may be modulated by concomitant potassium intake.

Most of the clinical trial evidence pertains to effects of minerals on risk factors (ie, BP and plasma lipids) that are relevant, intermediate outcomes for CVD. In addition, data primarily from observational studies provide evidence on the effects of dietary sodium and potassium on outcomes that are CVD events.

4.2. Selection of Inclusion/Exclusion Criteria

Work Group members developed eligibility criteria on the basis of a PICOTS approach for screening potential studies for inclusion in the evidence review. The PICOTS approach for CQ2 and other detailed methods are in the NHLBI Lifestyle Systematic Evidence Review report.

CQ2 was established to examine studies that assessed the impact of sodium and potassium on BP and cardiovascular morbidity and mortality. The studies included adults with or without established CVD; with or without CVD risk factors; with or without tobacco use; and who were of normal weight, overweight, or obese. In addition, intervention sample sizes were required to be at least 50 for biomarker and risk factor studies and 500 for cardiovascular morbidity and mortality. Because a separate Obesity Expert Panel reviewed evidence on the effect of weight loss on CVD risk factors and outcomes, the Work Group excluded studies in which weight change was >3%.

4.3. Literature Search Yield

In all, 34 studies (46 citations) satisfied the CQ2 inclusion criteria and were rated as good or fair quality.31,32,46,47,53–94

The CQ2 summary tables are available in the Full Work Group Report supplement. The tables present data on the studies used in the evidence review organized by mineral (sodium or potassium), outcomes (BP or CVD outcomes), sodium subquestions (overall results, different levels of sodium, sodium and other dietary changes), and subpopulations (sex, Summary Table C–4a; race/ethnicity, Summary Table C–4b; age, Summary Table C–4c; and hypertension status, Summary Table C–4d). Some studies appear in more than 1 summary table because they address more than 1 corresponding mineral or subquestion.

4.4. CQ2 Evidence Statements

See Table 13 for the CQ2 ESs for sodium and BP.

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Table 13.

CQ2 ESs for Sodium and BP

4.4.1. Sodium and BP

A note about the unit of measure presented for dietary and urinary sodium: sodium is presented in studies in millimoles (mmol), grams (g), and milligrams (mg). The Work Group chose to convert the sodium results to milligrams for the ESs, recommendations, and rationales so that data from different studies would be displayed in a consistent unit. Also, US dietary recommendations and the Nutrition Facts labels on food products display sodium in milligrams, and this unit (mg) will be easier for healthcare providers to communicate with patients. Urinary and dietary sodium are portrayed in the original units from each published study in the CQ2 summary tables (C–1 to C–8).

4.5. Diet Recommendations for BP Lowering

  • 1. Advise adults who would benefit from BP lowering to:

    • a. Consume a dietary pattern that emphasizes intake of vegetables, fruits, and whole grains; includes low-fat dairy products, poultry, fish, legumes, nontropical vegetable oils, and nuts; and limits intake of sweets, sugar-sweetened beverages, and red meats.

      • i. Adapt this dietary pattern to appropriate calorie requirements, personal and cultural food preferences, and nutrition therapy for other medical conditions (including diabetes).

      • ii. Achieve this pattern by following plans such as the DASH dietary pattern, the USDA Food Pattern, or the AHA Diet.

NHLBI Grade: A (strong); ACC/AHA COR: I, LOE: A

Rationale: This recommendation is based largely on studies of the DASH dietary pattern (DASH and DASH-Sodium), which provided the highest-quality evidence that this food-based dietary pattern improves lipid profiles and BP (Tables 8 and 9, CQ1 ES3–ES9). This evidence was supplemented by studies of low quality in which various adaptations of the MED pattern were tested and also found to reduce BP (Table 7, CQ1 ES1). The evidence suggests that the effects of the recommended dietary pattern persist as long as the pattern is consumed. The BP-lowering effect has been demonstrated in adults with hypertension and prehypertension and is evident in men and women, African-American and non–African-American adults, and older and younger adults (Table 8, ES5). The dietary pattern's effect on BP is independent of changes in weight and sodium intake. The magnitude of effect is sufficient to prevent progression from prehypertension to hypertension, promote nonpharmacological BP control in those with hypertension, and supplement pharmacological BP lowering.

The caloric (energy) intake should be appropriate for the individual (eg, restricted for those attempting weight loss). Patients should also be encouraged to adapt the recommended dietary pattern to their personal and cultural preferences. Materials are available to assist patients in achieving the recommended dietary pattern at different calorie levels (Table 9). The 2010 US Department of Health and Human Services Dietary Guidelines for Americans recommend the USDA Food Pattern and the DASH dietary pattern.49 Overall, the recommended dietary pattern is consistent with the AHA Diet50 and the USDA Food Pattern.49 The USDA Food Pattern offers lacto-ovo vegetarian and vegan adaptations. Therefore, this recommendation is consistent with other national guidelines. Clinicians should be familiar with the recommendations, advise their patients to adopt them, and provide easy access to information (Table 11). Dietary planning and nutritional counseling are often facilitated by referral to a nutrition professional.

  • 2. Advise adults who would benefit from BP lowering to:

    • a. Lower sodium intake

NHLBI Grade: A (strong); ACC/AHA COR: I, LOE: A

Rationale: There is strong and consistent clinical trial evidence that reducing sodium intake lowers BP. This BP-lowering effect has been demonstrated in adults with hypertension and prehypertension, in men and women, in African-American and non–African-American adults, and in older and younger adults. Trials contributing to this evidence include well-controlled feeding studies as well as studies in which participants were counseled to lower sodium intake. The effect of reducing sodium intake on BP is independent of changes in weight. The magnitude of effect is sufficient both to prevent progression from prehypertension to hypertension and to promote nonpharmacological BP control in those with hypertension. Observational data also suggest that lower sodium intake is associated with lower risk of cardiovascular events in people with and without hypertension, which is hypothesized to occur through reductions in BP.

  • 3. Advise adults who would benefit from BP lowering to:

    • a. Consume no more than 2400 mg of sodium/d;

    • b. Further reduction of sodium intake to 1500 mg/d can result in even greater reduction in BP;

    • c. Even without achieving these goals, reducing sodium intake by at least 1000 mg/d lowers BP.

NHLBI Grade: B (moderate); ACC/AHA COR: IIa, LOE: B

Rationale: One well-conducted trial demonstrated clinically meaningful lowering of BP when sodium was reduced to 2400 mg/d, with lower BPs achieved when sodium intake was reduced to 1500 mg/d. Reductions of 1000 mg/d were shown to be beneficial in trials, and observational studies estimated significant reductions in relative risk associated with changes in sodium intake of about 1000 mg/d. This recommendation is directed at the two thirds of the US adults who have prehypertension or hypertension, for whom reducing sodium intake can prevent or improve control of hypertension and potentially reduce cardiovascular events.

The Work Group acknowledges that the recommendation to reduce sodium intake to ≤2400 mg/d differs slightly from other current dietary recommendations—specifically, the 2010 Dietary Guidelines for Americans and the Institute of Medicine Dietary Reference Intakes; both of these publications recommend 2300 mg/d as the upper limit of intake for adults. Although the impact on behavior of a difference between intakes of 2400 mg of sodium/d versus 2300 mg of sodium/d would be minimal, these recommendations are based on the strongest clinical trial evidence available: the achieved level of 2400 mg/d from the DASH-Sodium trial (estimated from average urinary sodium excretion) (Table 11, CQ2 ES2).

The strength of this recommendation is graded “moderate” because fewer clinical trials were used to devise the 2400-mg and 1500-mg goals than the large number of trials used to inform the overall recommendation on sodium (dietary recommendation No. 2 for BP lowering), which is graded “strong.”

Reducing sodium intake can be challenging for an individual because of the ubiquitous nature of sodium in the American food supply. Educational materials with strategies to help patients lower sodium intake are provided by several federal and private sources.49,95–98 Ultimately, however, significant changes in sodium intake among US adults may require changes both in individual behavior and in food manufacturing and processing.

  • 4. Advise adults who would benefit from BP lowering to:

    • a. Combine the DASH dietary pattern with lower sodium intake.

NHLBI Grade: A (strong); ACC/AHA COR: I, LOE: A

Rationale: Both a healthy dietary pattern, as exemplified by DASH, and reduced sodium intake independently reduce BP. However, the BP-lowering effect is even greater when these dietary changes are combined. In the 60% of US adults with prehypertension or hypertension, simultaneously implementing dietary recommendations No. 1 and No. 2 for BP lowering can prevent and control hypertension more than either intervention alone.

5. CQ3—Physical Activity: Lipids and BP

See Table 14 for the CQ for physical activity and lipids and BP.

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Table 14.

CQ for Physical Activity: Lipids and BP

5.1. Introduction/Rationale

Large bodies of observational data show an association between higher levels of physical activity and lower rates of many chronic diseases, including CVD, and enhanced longevity.99–101 Furthermore, an inverse dose-response relation exists, with increasing higher levels of activity associated with commensurately lower rates of CVD in a curvilinear fashion.102,103 In a recent analysis, it was estimated that by eliminating physical inactivity, 6% of coronary heart disease worldwide may be eliminated, and life expectancy of the world population may be increased by 0.68 years.104,105

Among the mechanisms proposed to mediate the relationship between physical activity and decreased CVD rates are beneficial effects of exercise on lipid profile and BP.106 In one study, it was estimated that the beneficial effects of physical activity on BP and development of hypertension explained some 27% of the activity-related reduction in observed CVD rates, while 19% and 16% of the reduction in CVD rates could be explained by the beneficial effects of physical activity on traditional lipids and novel lipids, respectively.

In the remainder of Section 5, the Work Group elaborates on findings from meta-analyses of the effects of physical activity on changes in lipid profile and BP.

5.2. Selection of Inclusion/Exclusion Criteria

Because of resource limitations, the Work Group included only systematic reviews and meta-analyses of RCTs or controlled clinical trials published from 2001 through 2011. Detailed inclusion/exclusion criteria are available in the Full Work Group Report supplement.

5.3. Literature Search Yield

A total of 26 systematic reviews and meta-analyses were identified that met inclusion/exclusion criteria and were rated as good or fair quality.105,107–130

The CQ3 subcommittee members next identified the included systematic reviews and meta-analyses that contained detailed data on BP outcomes. They identified 11 studies with data on BP outcomes. Ten meta-analyses and 1 systematic review examined the effects of aerobic exercise. One systematic review looked at the effects of resistance training. The CQ3 subcommittee members next identified the included systematic reviews and meta-analyses that contained detailed data on lipid outcomes. They identified 14 studies with data on lipid outcomes, including 10 meta-analyses and 4 systematic reviews.

The next step in the evidence review process for systematic reviews and meta-analyses was to develop ESs and recommendations from the included studies and present them to the full Work Group for consideration and voting. Because each of these systematic reviews and meta-analyses summarizes evidence from several studies, NHLBI staff and Work Group members determined that the development of formal evidence tables and summary tables of individual articles was unnecessary. CQ3 subcommittee members developed evidence tables that are available in the Full Work Group Report supplement (CQ3 Summary Tables: Summary Table D–1: Aerobic Exercise and LDL-C, Summary Table D–2: Resistance Exercise and LDL-C, Summary Table D–3: Aerobic Exercise and HDL-C, and Summary Table D–4: Resistance Exercise and HDL-C) to summarize the evidence on physical activity and lipids.

5.4. CQ3 Evidence Statements

5.4.1. Physical Activity and Lipids

See Table 15 for the CQ3 ESs for physical activity and lipids.

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Table 15.

ESs for Physical Activity and Lipids

This section examines evidence supporting the use of physical activity alone (ie, not in combination with other interventions, such as dietary interventions or weight loss) versus no physical activity or other type of intervention for improvements in selected blood lipids (HDL-C, LDL-C, triglycerides, and non–HDL-C). The 2008 Physical Activity Guidelines Advisory Committee Report was used as the starting point for evidence review.99 Additionally, a systematic search identified 8 meta-analyses from 2001 onward and 5 systematic reviews rated fair to good that addressed this question and were included as the evidence base.

5.4.2. Physical Activity and BP

This section examines evidence supporting the use of physical activity alone (ie, not in combination with other interventions, such as dietary interventions or weight loss) versus no physical activity or other types of intervention for BP reduction. The 2008 Physical Activity Guidelines Advisory Committee Report was used as the starting point for evidence review.99 Additionally, a systematic search identified 15 meta-analyses from 2001 onward and reviews rated fair to good that addressed this question. Details of the search are provided in the Full Work Group Report supplement.

5.4.2.1. Aerobic Exercise Training and BP

See Table 16 for the ES for aerobic exercise training and BP.

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Table 16.

ES for Aerobic Exercise Training and BP

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Table 17.

Heart-Healthy Nutrition and Physical Activity Behaviors

5.4.2.2. Resistance Exercise Training and BP

The 2008 Physical Activity Guidelines Advisory Committee focused on data from a meta-analysis of 9 RCTs of resistance training that included 341 subjects.131 However, given the limited parameters of the systematic search described previously for CQ3 (Section 5.3), only 1 review was identified. A qualitative review of clinical trials—randomized, nonrandomized, and uncontrolled studies—examined resistance exercise training in relation to metabolic health among patients with type 2 diabetes.127 Ten of these studies assessed BP. Investigators concluded that resistance exercise training resulted in beneficial changes in systolic BP, with benefits in diastolic BP observed less frequently. (The magnitude of reduction was not specified.) Thus, the review of evidence did not provide consistent evidence on resistance exercise training for BP reduction.

5.4.2.3. Combination of Aerobic and Resistance Exercise Training and BP

There have been no published meta-analyses or reviews specifically examining the effect of a combined regimen of aerobic exercise and resistance training on BP. However, in some of the meta-analyses and reviews described above, studies with aerobic and resistance components were included in pooled data related to aerobic exercise training.113,114

5.5. Physical Activity Recommendations

  • 1. In general, advise adults to engage in aerobic physical activity to reduce LDL-C and non–HDL-C: 3 to 4 sessions per week, lasting on average 40 minutes per session, and involving moderate- to vigorous-intensity physical activity.

NHLBI Grade: B (moderate); ACC/AHA COR: IIa, LOE: A

Rationale: This recommendation was based on evidence from meta-analyses and reviews published from 2001 onward and rated fair to good. This is also consistent with the findings of the literature review conducted for the 2008 Physical Activity Guidelines Advisory Committee Report, in which it was found that it may require 12 metabolic equivalent task-hours per week of exercise to favorably influence LDL-C. The amount of physical activity recommended above for reducing LDL-C and non–HDL-C is congruent with the amount of physical activity recommended in 2008 by the federal government for overall health: “Most health benefits occur with at least 150 minutes (2 hours and 30 minutes) a week of moderate-intensity physical activity, such as brisk walking. Additional benefits occur with more physical activity.”99

  • 2. In general, advise adults to engage in aerobic physical activity to lower BP: 3 to 4 sessions per week, lasting on average 40 minutes per session, and involving moderate- to vigorous-intensity physical activity.

NHLBI Grade: B (moderate); ACC/AHA COR: IIa, LOE: A

Rationale: This recommendation was based on evidence from meta-analyses and reviews rated fair to good that were published from 2001 onward, as well as the 2008 Physical Activity Guidelines Advisory Committee Report. The amount of physical activity recommended above for lowering BP is congruent with the amount of physical activity recommended in 2008 by the federal government for overall health: “Most health benefits occur with at least 150 minutes (2 hours and 30 minutes) a week of moderate-intensity physical activity, such as brisk walking. Additional benefits occur with more physical activity.”99 It is worth noting that the present recommendation is congruent with (ie, expends approximately the same amount of energy) but not identical to the 2008 federal guidelines. This is because the present recommendation is based on a review of meta-analyses of exercise in relation to BP only (hence, the specific regimens as used in the clinical trials), whereas the 2008 federal guidelines targeted overall health (ie, not just BP). Additionally, the 2008 federal guidelines for overall health make it clear that any amount of physical activity is healthful (“Some physical activity is better than none”), and that there is a dose-response relationship (“For most health outcomes, additional benefits occur as the amount of physical activity increases through higher intensity, greater frequency, and/or longer duration”).

5.6. Heart-Healthy Nutrition and Physical Activity Behaviors

See Table 17 for information on heart-healthy nutrition and physical activity behaviors.

Overall, the Work Group encourages heart-healthy nutrition and physical activity behaviors for the entire US adult population as stated in the 2010 Dietary Guidelines for Americans and the 2008 Physical Activity Guidelines for Americans. The recommendations in Table 17 are a consensus of the Work Group, not a guideline, and are generally consistent with the 2010 Dietary Guidelines for Americans and the 2008 Physical Activity Guidelines for Americans.

6. Gaps in Evidence and Future Research Needs

6.1. Diet

The extensive work of the Work Group served an additional purpose, and that was to identify important gaps in the knowledge of how lifestyle impacts CVD risk reduction. Additional research is needed on the following topics related to diet:

  • Interaction between dietary modification and statin treatment.

    Relative effects of saturated fats, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids, omega-3 fatty acids, and types of carbohydrates on lipids, inflammation, microbiome, and other newer potential CVD risk factors.

    Relative effects of naturally occurring fiber (cereal [whole grains] and vegetable/fruit) and supplemental fiber on lipids, inflammation, microbiome, and other newer potential CVD risk factors.

    Effects of dietary cholesterol on LDL-C and HDL-C over the current ranges of cholesterol and saturated fat intakes (5th and 95th percentiles).

    Effects of minerals in combination (other than sodium) on BP.

    High-density lipoprotein function in studies that modify HDL-C by changes in diet.

    Is the minimal effect of dietary carbohydrate on plasma triglycerides harmful?

    The effect of sodium reduction in patients with diabetes, heart failure, and chronic kidney disease.

    Effect of dietary pattern and sodium intake in adults taking BP-lowering or lipid-lowering medications (eg, effects on BP/lipids, achieving BP/lipid goals, medication needs/costs, outcomes).

    Effect of dietary pattern and sodium intake in adults with CVD (eg, after myocardial infarction; after stroke; with coronary artery disease, heart failure, or chronic kidney disease).

    Strategies for effectively (and cost-effectively) implementing these evidence-based recommendations. (How can primary care providers, health systems, public health agencies, local and federal government, community organizations, and other stakeholders help patients adopt these diet and sodium intake recommendations?)

    Increased understanding of racial/ethnic/socioeconomic factors that may influence (a) effect of dietary pattern and sodium on BP and lipids, (b) adoption of diet/sodium recommendations, and (c) method of diet assessment.

6.2. Physical Activity

Additional research is needed on the following topics related to physical activity:

  • Improved understanding of whether exercise performed at a lower intensity or dose, or different modes of exercise, can impact these outcomes.

    Further understanding the characteristics of individuals for whom exercise of a certain dose or intensity can reduce LDL-C and non–HDL-C.

    Understand the source of the inconsistent findings to better understand under what conditions exercise can increase HDL-C or decrease triglycerides.

    Define the optimal dose of exercise that will result in the desired changes in lipids and lipoproteins and whether exercise performed at a lower intensity or dose, or different modes of exercise, can impact these outcomes.

    Further understand the characteristics of individuals for whom exercise of a certain dose, intensity, or mode can increase HDL-C or reduce triglycerides.

    Clarify the shape of the dose-response curve between physical activity and BP.

    Expand the limited data on whether resistance exercise training lowers BP and whether a combination of aerobic and resistance exercise training offers any added BP lowering, compared with aerobic exercise only.

    Determine how diet and physical activity behave synergistically with regard to lipids and BP.

    Determine the effect of physical activity in adults taking BP-lowering and/or lipid-lowering medications (eg, effects on BP/lipids, achieving BP/lipid goals, medication needs/costs, outcomes).

    Determine the effect of physical activity in adults with CVD (eg, after myocardial infarction; after stroke; with coronary artery disease, heart failure, or chronic kidney disease).

    Determine strategies for effectively (and cost-effectively) implementing these evidence-based recommendations. (How can primary care providers, health systems, public health agencies, local and federal government, community organizations, and other stakeholders help patients adopt these physical activity recommendations?)

    Increase understanding of racial/ethnic/socioeconomic factors that may influence (a) effect of physical activity on BP and lipids and (b) adoption of physical activity recommendations.

Presidents and Staff

American College of Cardiology

John Gordon Harold, MD, MACC, President

Shalom Jacobovitz, Chief Executive Officer

William J. Oetgen, MD, MBA, FACC, Executive Vice President, Science, Education, and Quality

Charlene L. May, Senior Director, Science and Clinical Policy

American College of Cardiology/American Heart Association

Lisa Bradfield, CAE, Director, Science and Clinical Policy

Emily Cottrell, MA, Specialist, Science and Clinical Policy

American Heart Association

Mariell Jessup, MD, FACC, FAHA, President

Nancy Brown, Chief Executive Officer

Rose Marie Robertson, MD, FAHA, Chief Science Officer

Gayle R. Whitman, PhD, RN, FAHA, FAAN, Senior Vice President, Office of Science Operations

Marco Di Buono, PhD, Vice President of Science and Research

Jody Hundley, Production Manager, Scientific Publications, Office of Science Operations

National Heart, Lung, and Blood Institute

Kathryn Y. McMurry, MS

Glen Bennett, MPH

Denise G. Simons-Morton, MD, PhD

Appendix

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Appendix 1.

Author Relationships With Industry and Other Entities (Relevant)—2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk

Appendix

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Appendix 2.

Expert Reviewer Relationships With Industry and Other Entities—2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk

Appendix

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Appendix 3.

Abbreviations

Footnotes

  • Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, American Pharmacists Association, American Society for Nutrition, American Society for Preventive Cardiology, American Society of Hypertension, Association of Black Cardiologists, National Lipid Association, Preventive Cardiovascular Nurses Association, and WomenHeart: The National Coalition for Women With Heart Disease

  • EXPERT WORK GROUP MEMBERS

  • METHODOLOGY MEMBERS

  • Karima A. Kendall, PhD; Laura C. Morgan, MA; Michael G. Trisolini, PhD, MBA; George Velasco; Janusz Wnek, PhD

  • ACC/AHA TASK FORCE MEMBERS

  • Jeffrey L. Anderson, MD, FACC, FAHA, Chair; Jonathan L. Halperin, MD, FACC, FAHA, Chair-Elect; Nancy M. Albert, PhD, CCNS, CCRN, FAHA; Biykem Bozkurt, MD, PhD, FACC, FAHA; Ralph G. Brindis, MD, MPH, MACC; Lesley H. Curtis, PhD, FAHA; David DeMets, PhD; Judith S. Hochman, MD, FACC, FAHA; Richard J. Kovacs, MD, FACC, FAHA; E. Magnus Ohman, MD, FACC; Susan J. Pressler, PhD, RN, FAAN, FAHA; Frank W. Sellke, MD, FACC, FAHA; Win-Kuang Shen, MD, FACC, FAHA

  • SUBCOMMITTEE ON PREVENTION GUIDELINES

  • Sidney C. Smith, Jr, MD, FACC, FAHA, Chair; Gordon F. Tomaselli, MD, FACC, FAHA, Co-Chair

  • ↵* Ex-Officio Members.

  • This document was approved by the American College of Cardiology Board of Trustees and the American Heart Association Science Advisory and Coordinating Committee in November 2013. The Academy of Nutrition and Dietetics affirms the value of this guideline.

  • The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/01.cir.0000437740.48606.d1/-/DC1.

  • The American Heart Association requests that this document be cited as follows: Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, Lee I-M, Lichtenstein AH, Loria CM, Millen BE, Nonas CA, Sacks FM, Smith SC Jr, Svetkey LP, Wadden TA, Yanovski SZ. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(suppl 2):S76–S99.

  • This article is copublished in the Journal of the American College of Cardiology.

  • Copies: This document is available on the World Wide Web sites of the American College of Cardiology (www.cardiosource.org) and the American Heart Association (my.americanheart.org). A copy of the document is available at http://my.americanheart.org/statements by selecting either the “By Topic” link or the “By Publication Date” link. To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay{at}wolterskluwer.com.

  • Expert peer review of AHA Scientific Statements is conducted by the AHA Office of Science Operations. For more on AHA statements and guidelines development, visit http://my.americanheart.org/statements and select the “Policies and Development” link.

  • ↵* Refer to the 2013 Blood Cholesterol Guideline4 for guidance on who would benefit from LDL-C lowering.

  • © 2013 The Expert Work Group Members.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer; the Journal of the American College of Cardiology is published on behalf of the American College of Cardiology Foundation by Elsevier Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the Contribution is properly cited, the use is non-commercial, and no modifications or adaptations are made.

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Circulation
June 24, 2014, Volume 129, Issue 25 suppl 2
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    • Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk
    • 2. Lifestyle Management Recommendations
    • 3. CQ1—Dietary Patterns and Macronutrients: BP and Lipids
    • 4. CQ2—Sodium and Potassium: BP and CVD Outcomes
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    2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk
    Robert H. Eckel, John M. Jakicic, Jamy D. Ard, Janet M. de Jesus, Nancy Houston Miller, Van S. Hubbard, I-Min Lee, Alice H. Lichtenstein, Catherine M. Loria, Barbara E. Millen, Cathy A. Nonas, Frank M. Sacks, Sidney C. Smith, Laura P. Svetkey, Thomas A. Wadden and Susan Z. Yanovski
    Circulation. 2014;129:S76-S99, originally published November 12, 2013
    https://doi.org/10.1161/01.cir.0000437740.48606.d1

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    2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk
    Robert H. Eckel, John M. Jakicic, Jamy D. Ard, Janet M. de Jesus, Nancy Houston Miller, Van S. Hubbard, I-Min Lee, Alice H. Lichtenstein, Catherine M. Loria, Barbara E. Millen, Cathy A. Nonas, Frank M. Sacks, Sidney C. Smith, Laura P. Svetkey, Thomas A. Wadden and Susan Z. Yanovski
    Circulation. 2014;129:S76-S99, originally published November 12, 2013
    https://doi.org/10.1161/01.cir.0000437740.48606.d1
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