Letter by Jones et al Regarding Article, “Elevated Remnant Cholesterol Causes Both Low-Grade Inflammation and Ischemic Heart Disease, Whereas Elevated Low-Density Lipoprotein Cholesterol Causes Ischemic Heart Disease Without Inflammation”
To the Editor:
Two recent studies published by Varbo et al1,2 report causal associations of remnant lipoprotein cholesterol (RLP-C) with cardiovascular outcomes. The most recent report shows the effects of low-density lipoprotein (LDL) cholesterol (LDL-C) acting directly to promote ischemic heart disease and suggests a causal relationship of RLP-C with low-grade systemic inflammation. We applaud the authors for these contributions supporting the importance and causal role of triglyceride (TG)-rich lipoproteins in atherogenesis and subsequent atherothrombotic risk.