Abstract 9845: Alcohol Consumption and Risk of Cardiovascular Disease
Background: Since the discovery of fermented beverage, alcohol has been the most widely used recreational drink for mankind. However, impact of alcohol consumption on CVD remains unclear.
Methods: We conducted prospective nationwide cohort study (Korean national health insurance service cohort), including 18,080,391 Korean adults (age ≥19), to provide new evidence on the effect of alcohol consumption on CVD. Nationwide biennial health check-up results and national health information/surveillance system data were gathered during study period. Cox proportional hazard models were used to study the association between weekly alcohol consumption dose [none (reference), 60-119g, 120-179g, 180-239g, 240-419g, and ≥420g] and CVD events after adjusting for age, gender, body mass index (kg/m2), hypertension, diabetes, hemoglobin level (g/dl), total cholesterol level (mg/dl), smoking status, physical activity, and diet style.
Results: The mean age of the subjects was 43.9±14.6 years, 53.9% were men, and 49.1% were alcohol drinkers. During mean follow-up period of 5.0 years, CVD developed in 211,202 subjects (coronary heart disease, 35,060; ischemic stroke, 137,426; intracerebral hemorrhage, 24,429; subarachnoid hemorrhage, 14,287). In multivariable adjusted analysis, protective effect of alcohol consumption was observed in all doses for coronary heart disease (maximum in ≥420g category, HR 0.47, 95% CI 0.43-0.51) and ischemic stroke (maximum in 120~179g category, HR 0.79, 95% CI 0.76-0.83). Harmful effect of alcohol consumption was observed in all doses for intracerebral hemorrhage and subarachnoid hemorrhage, with significant linear trend. Alcohol consumption reduced risk of total CVD events in all doses (maximum in 120~179g category, HR 0.81, 95% CI 0.79-0.84).
Conclusions: Alcohol consumption is associated with reduced risk of overall CVD events, despite of deleterious association with hemorrhagic stroke.
- © 2013 by American Heart Association, Inc.