Abstract 9642: An Image Based Evaluation of Dynamic Heart Function Following Different Cardiopulmonary Bypass Techniques, Using New High-Resolution 4D Echocardiography
Background: In this study, we evaluated the impact of different cardiopulmonary bypass methods on dynamic heart function.
Methods: We studied 12 open-chest piglets (3-5kg). Body temperature, oxygen saturation, blood gases and vital signs were continually monitored. Baseline 4D full volume image loops were acquired from the heart surface with a 4Z1c matrix transducer on a Siemens SC 2000 ultrasound system at frame rate > 30 VPS. Five piglets were subjected to cross-circulation cardiopulmonary bypass for 2 hours using an adult matched donor. Seven piglets were subjected to conventional bypass for the same duration, 3 with matched blood at body temperature (normothermic) and 4 with matched hypothermic blood. After 2 hours of bypass, normal circulation was restored, 4D images acquired after stabilization and images were analyzed offline using VMM motion analysis software from Siemens.
Results: In piglets with cross-circulation, average peak apical and basal rotation was slightly increased (0.25-0.95°) and average peak strain (both circumferential and longitudinal) values were diminished in all segments (2.25-4.15%, p=0.039). Piglets with normothermic cardiopulmonary bypass showed similar mechanical changes in LV strain and rotation (p=0.017). Piglets with hypothermic bypass, however, showed a greater increase in LV rotation (1.25-1.75°) and greater depression of strain values (4.25-6.15%).
Conclusion: New 4D echo is feasible to monitor dynamic heart function after cardiopulmonary bypass.
- © 2013 by American Heart Association, Inc.