Abstract 9449: Feasibility and Accuracy of High Resolution 4D Echocardiography for Evaluation of Left Ventricular Mass and Stroke Volume: An in vitro Phantom Study
Background: This study was designed to determine the accuracy and feasibility of a new 4D echo-based semi-automated quantification of left ventricular (LV) mass (LVM) and stroke volume (SV) in an in vitro phantom model.
Methods: Ten freshly harvested adult pig and sheep hearts (147-326 grams) were passively driven using a pulsatile pump to simulate normal cardiac motion. Each heart was pumped at 3 stroke rates (SR) (40, 65, and 85 strokes/min) and 3 SVs (30, 50, and 70 ml at each SR). Full-volume 4D cine loops were collected with a 3V Matrix transducer interfaced with a GE Vivid E9 ultrasound system at a maximized frame rate (≥25 FPS) using multi-beat acquisition. Images were analyzed offline using EchoPAC PC for semi-automated quantification of SV and LVM and compared to displacement values.
Results: No significant differences were detected between the values of either SV or LVM at different stroke rates (P=0.99). Data showed excellent linear correlation between 4D echo-derived SV and LVM, and displacement data (SV: R2=0.96, p<0.001; LVM: R2=0.99, p<0.001). Bland-Altman analyses revealed 98% and 99% of points within a 95% CI for SV and LVM respectively. Interobserver variability was shown to be excellent (SV: R2=0.92, p<0.001; LVM: R2=0.99, p<0.001).
Conclusions: 4D echo-based quantification may be an accurate and feasible method for determination of LV mass and stoke volume and a physiologically relevant range of stroke volumes and stroke rates.
- © 2013 by American Heart Association, Inc.