Abstract 9393: Anxiety and Depressive Symptoms Have Inverse Relationships With Cardiac Depolarization by ECG: MESA Study
BACKGROUND: Depression and anxiety are predictors of poor cardiac prognosis. Lower T wave amplitude by resting electrocardiogram (ECG) has been correlated with adverse outcomes such as myocardial infarction, cardiac mortality, and sudden cardiac death. We therefore examined the relationship between depressive and anxiety symptoms and T wave amplitude in the Multi-Ethnic Study of Atherosclerosis (MESA).
METHODS: Men and women 45 to 84 years old, free of clinically apparent cardiovascular disease, were recruited between July 2000 and August 2002 from six US communities. Resting 12-lead ECGs were collected, depressive symptoms were measured with the Center for Epidemiologic Studies-Depression scale (CES-D) and anxiety symptoms were measured with the Spielberger Trait Anxiety scale. Linear regression models with maximum T wave amplitude in microvolts as the dependent variable and depression and anxiety scores as independent variables were utilized for analysis. Participant were excluded for any of the following: QRS duration >120 msec, major ECG abnormalities according to the Minnesota Code, or use of antiarrhythmic, antidepressant, or antipsychotic medication.
Results: Of 6814 MESA participants, 5388 met the inclusion criteria and were retained for analysis. Depressive symptom scores and anxiety scores were moderately correlated (r=0.55). With simultaneous inclusion in multivariable models that adjusted for cardiovascular disease confounders, depressive symptoms were associated with lower T wave amplitude, while symptoms of anxiety were associated with higher T wave amplitude.
CONCLUSION: In this group of men and women without known cardiovascular disease, depressive symptoms were associated with lower T wave amplitude while anxiety symptoms were unexpectedly associated with higher T wave amplitude. Further investigation of the associations of these negative mood states with cardiac repolarization is warranted.
- © 2013 by American Heart Association, Inc.