Regulation of Plasma Lipoprotein Levels in Humans: New Insights Using Methods Pioneered by Bob Levy
In the early 1970s, Robert Levy and colleagues published a series of groundbreaking papers showing, in detail, the metabolic fates of the apolipoproteins on very low density lipoproteins after intravenous injection into normal and hyperlipidemic subjects. These studies were the foundation for the field of human lipoprotein kinetics that has provided very significant insights into the pathophysiology of lipid disorders as well as mechanisms of action of lipid altering diets and drugs. Early studies used mainly exogenously radiolabeled lipoproteins, but more recently, stable isotopes of amino acids have been used to endogenously label the apolipoproteins of interest. Our group has used both approaches for more than three decades and in this lecture, I will highlight the results of several of our studies including very recent unpublished work.
- © 2013 by American Heart Association, Inc.