The Regression of Atherosclerosis: The Journey From the Liver to the Plaque and Back
The Duff Memorial Award Lecture will consist of 3 short stories. In the first, new developments will be presented on how the production of very low density lipoproteins (VLDL, which become LDL) by the liver is controlled by the degradation of their apolipoprotein B (apoB) component. In particular, our recent results have shown that insulin and niacin, two medically relevant regulators of the plasma levels of VLDL, utilize a process called autophagy to accomplish this. In the second, recent studies on the regression of atherosclerosis in novel mouse models will be presented. Specifically, I will show that to get rid of the cholesterol-filled disease-causing cells from the arterial plaques, new, healthy, monocytes need to be recruited from the circulation. In the third story, the use of natural and synthetic nanoparticles to carry imaging and therapeutic agents directly to atherosclerotic plaques will be presented.
- © 2013 by American Heart Association, Inc.