Abstract 220: Development of a Supraglottic Airway Device with the Function of Pharyngeal Cooling
Introduction: Intra-ischemic brain hypothermia has shown better neuroprotective effects when it is initiated earlier after the onset of resuscitation. To initiate brain hypothermia simultaneously with airway management at the beginning of resuscitation, we developed a supraglottic airway device that enables initiation of pharyngeal cooling. The effects of the airway device on brain temperature were evaluated.
Methods: A Japanese monkey (10 kg) was anesthetized with isoflurane. The airway was maintained with our newly developed supraglottic airway device. Artificial ventilation was performed with tidal volume = 100 ml, respiratory rate = 20±5 times /min and peak airway pressure < 20 cmH2O. PaCO2 was maintained at 40±5 mmHg. Right epidural temperature (parietal cortex), right sub-cortical temperature (3 cm below the cortical surface) and rectal temperature were monitored. A pharyngeal cooling cuff attached under the supraglottic airway device was perfused with physiological saline (5 °C) at the rate of 500 ml/min for 60 min. Intracuff pressure was maintained < 50 cmH2O.
Result: Initiation of pharyngeal cooling did not affect respiratory conditions, including peak airway pressure and PaCO2. Epidural temperature had decreased by 3.1 °C and 4.7°C at 30 min and 60 min after the onset of cooling, respectively. Sub-cortical temperature had decreased by 2.7°C and 4.2 °C at 30 min and 60 min after the onset of cooling, respectively. Rectal temperature had decreased by 1.9 °C and 3.2 °C at 30 min and 60 min after the onset of cooling, respectively.
Conclusion: The supraglottic airway device with the function of pharyngeal cooling can reduce the onset time for initiation of brain cooling.
- © 2013 by American Heart Association, Inc.