Abstract 19090: Assessing the Contribution of Dietary Factors to the Increased Prevalence of Insulin Resistance Amongst Uk Indian Asians Compared to Europeans
Background: Indian Asians comprise a quarter of the world’s population. Insulin resistance (IR) is highly prevalent amongst Indian Asians, contributing to their 4-fold higher risk of type-2 diabetes (T2D) compared to Europeans.
Unfavourable diet (high intake of total and saturated fat, and high glycaemic index foods) is an important determinant of IR. We carried out chemical analysis of duplicate diet samples to investigate whether unfavourable diet contributes to higher risk of IR and T2D in Indian Asians compared to Europeans.
Methods: We recruited 92 Indian Asian and 94 European men from the lists of primary care physicians in West London (UK). Clinical characterisation included clinical questionnaire, anthropometric measurements and fasting blood samples (including lipid profile, glucose and insulin). Two 24-hour duplicate diets (comprising duplicate portions of all food and drink consumed) were collected, weighed, and homogenised. 30 ml aliquots were sent for chemical analysis (lipids - gas chromatography; carbohydrate - spectrophotometer quantification; protein - Kjeldahl method).
Results: UK Indian Asians had higher body mass index, waist hip ratio, fasting insulin and were more insulin resistant [homeostatic model assessment-IR (HOMA[[Unable to Display Character: –]]IR)] than Europeans. Intakes of total protein, total fat and monounsaturated fat were lower, carbohydrate higher, and saturated, polyunsaturated and trans fat similar among Indian Asians compared to Europeans. HOMA[[Unable to Display Character: –]]IR was 32% (95% CI, 17[[Unable to Display Character: –]]46%) higher in Indian Asians (p<0.001). In multivariate regression, differences in macronutrients (including fatty acids, p<0.001) did not account for higher HOMA[[Unable to Display Character: –]]IR in Indian Asians.
Conclusion: Unfavourable diet does not account for the differences in prevalence of IR amongst Indian Asians compared to Europeans. Metabolic profiling of diet samples and plasma may help identify the role of fatty acids and micronutrients with increasing susceptibility to IR in Indian Asians.
- © 2013 by American Heart Association, Inc.