Abstract 18931: The Effect of Breaking Advanced Glycation End-Products, With or Without Exercise Training on the Cardiovascular Effects of Aging
Introduction: Sedentary aging impairs cardiovascular (CV) structure and function. Lifelong exercise training maintains youthful left ventricular (LV) and vascular structure but has little effect on relaxation. Moreover, exercise has no effect on CV structure when begun later in life, perhaps because of the accumulation of advanced glvcation end-products (AGE). Alagebrium is a crosslink breaker that improves LV compliance in older animals, especially when combined with exercise training. We hypothesised that exercise combined with Alagebrium would improve LV function in sedentary humans.
Methods: This was a dual-centre double-blind placebo controlled randomized trial with a 1-year intervention. We recruited 110 healthy subjects from the Dallas, TX (n=62) and Nijmegen, Netherlands (n=48). Subjects were randomized to either: a) no exercise+placebo; b) no exercise+Alagebrium [200mg/day]; c) Exercise+placebo; and d) Exercise+Alagebrium. We measured (VO2 max) and used 2-D echo for measurement of speckle tracking imaging (global longitudinal strain [GLS], systolic strain rate [SR], early diastolic strain rate [SR] and late diastolic strain rate [AR]).
Results: Ninety-nine subjects (age 68±5yrs; 53f/46m) completed the 1-year intervention. There were no group differences at baseline for VO2 max, GLS, SR, ER or AR. Exercise training increased VO2 max (P<0.001) without an additive effect of drug (P=0.79). There was no effect of drug, training, or any combination on GLS (P values ranged from 0.24-0.57), SR (P=0.77- 0.91), ER (P=0.37- 0.63), AR (P=0.09 - 0.20) [Table 1].
Conclusion: One-year of exercise training, AGE cross link inhibition or their combination does not significantly improve LV function measured by speckle tracking in previously sedentary seniors.
- © 2013 by American Heart Association, Inc.