Abstract 18900: Impact of Acute and Chronic 5-Hour Energy Drink Consumption on Electrocardiographic Parameters
INTRODUCTION: The impact of energy drinks on the cardiac rhythm remains unknown. QT/QTc prolongation has been known to induce life threatening arrhythmias. We sought to determine the impact of 5-Hour Energy shot on the QTc interval after acute and chronic consumption.
Methods: This was a randomized, placebo controlled, crossover study enrolling young healthy volunteers not on any medications. Subjects received the study drink (5 Hour Energy shot or placebo) twice daily separated by approximately 7 hours for the first 7 days. This was followed by a washout period of 6 days and the alternate study drink was consumed for the final 7 days. A 12-lead electrocardiogram was performed at baseline, 1, 3 and 5 hours on days 1, 7, 15 and 21. Automated ECG measurements were used for per-treatment and ITT analysis and analyzed using the paired student’s t-test.
Results: A total of 24 subjects (29±5.8 years) were included for analysis. QTc values after consumption of a single placebo-dose were 414±18, 413±15, 413±19 and 417±19 milliseconds at baseline, 1, 3 and 5 hours respectively. Post consumption of a single 5 Hour Energy dose, QTc values were 415±17, 408±19, 410±20, and 413±17 milliseconds at baseline, 1, 3 and 5 hours, respectively (all time matched inter- group p-values >0.291). QTc values after consumption of placebo for 7 days were 415±20, 413±18, 409±19, and 413±22 milliseconds at baseline, 1, 3 and 5 hours, respectively. Post consumption of 5 Hour Energy shots for 7 days, resulted in QTc values of 415±22, 413±24, 415±24, and 415±21 milliseconds at baseline, 1, 3 and 5 hours, respectively (all time matched inter- group p-values >0.197 ). There was no difference between the PR interval, QRS duration, QT interval and heart rate between the two groups.
CONCLUSION: 5-Hour Energy did not induce any significant changes in the QTc interval or other ECG parameters after single and multiple doses throughout a 7 day period. These results may vary between different energy drinks due to the varying ingredients within them. DISCLOSURE: The views expressed in this material are those of the authors and do not reflect the official policy or position of the U.S. government, the Department of Defense, or the Department of the Air Force.
- © 2013 by American Heart Association, Inc.