Abstract 18745: Outcomes of Mechanical Circulatory Support for Patients With Functionally Single-Ventricle Physiology at Different Stages of Surgical Palliation
Introduction: Mechanical circulatory support (MCS) for functionally single ventricle (SV) physiology poses significant challenges. We sought to analyze the results of MCS at 4 different stages of the surgical palliation process.
Methods: From 2003 to 2013, 86 SV patients required MCS: Group 1, before any surgical palliation (n=13, 15%), Group 2, between stage I and II (n=59, 69%), Group 3, between stage II and Fontan (n=10, 12%), Group 4, after Fontan (n=4, 5%). Indications for MCS included failure to wean from cardiopulmonary bypass in 6 (7%) patients, circulatory failure in 7 (8%), respiratory failure in 9 (10%), cardiopulmonary failure in 4 (5%), and cardiac arrest in 58 (67%). Kaplan-Meier analysis was used to compare freedom from death and freedom from failure to wean between groups. Cox analysis was used to determine risk factors.
Results: The median MCS duration was 3 days (IQR, 1-6). Of 86 patients, 58 (67%) were successfully weaned: 32 (37%) patients recovered, 8 (9%) were transplanted, 12 (14%) had operation/reoperation, and 1 (1%) had conversion to a different form of MCS. Fifty-two (60%) patients had complications including bleeding in 20, thromboembolism in 9, sepsis in 12, neurologic injury in 6, and multi-organ failure in 5. Thirteen patients required a second run of MCS. Freedom from death at 6 months after MCS initiation was comparable between the groups (Group 1, 23%, Group 2, 33%, Group 3, 15%, Group 4, 50%, p=0.66; Figure 1). Failure to wean from MCS was also comparable among the groups (p=0.46). Cox analysis revealed MCS-related complications as a risk factor for death (p=0.006) and longer duration of arrest as a risk factor for inability to wean from ECMO (p=0.036). The timing of MCS was not a risk factor for poor outcomes.
Conclusions: Two thirds of SV patients who required MCS were rescued, although subsequent survival is generally poor across all stages of palliation. Given the poor outcomes in this cohort, consideration of alternative strategies is warranted.
- © 2013 by American Heart Association, Inc.