Abstract 18739: Novel Protein Glycan Derived Marker of Systemic Inflammation is Associated With Incident Cardiovascular Disease
Background: Enzymatically glycosylated proteins partake in multiple cellular processes, with variations in their concentration implicated in innate immunity and chronic inflammation. In addition, most inflammatory proteins are enzymatically glycosylated. GlycA is a novel nuclear magnetic resonance (NMR) biomarker whose signal originates from the N-acetyl groups of N-acetylglucosmine and N-acetylgalatosamine moieties of protein glycans. We tested the hypothesis that GlycA is related to incident CVD and compared it with high sensitivity C-reactive protein (hsCRP)
Method: Baseline GlycA was quantified by NMR spectroscopy (LipoScience, NC) in 27 649 participants of the Women’s Health Study. A total of 1 651 cases of incident CVD events occurred during a median follow up of 17 years
Results: GlycA correlated with LDL cholesterol (r = 0.17), HDL cholesterol (r = -0.27), triglycerides (r = 0.47), BMI (r = 0.41) and hsCRP (r = 0.61), all p<0.0001. Multivariable-adjusted Cox regression HRs (95% CIs) across increasing quartiles of GlycA for incident CVD were 1.00, 1.10 (0.92-1.30), 1.34 (1.14-1.58) and 1.64 (1.39-1.94), p trend <0.0001, similar in magnitude to the association of hsCRP with CVD (Table). The association of GlycA with CVD was attenuated but remained significant after additional adjustment for lipids (p-trend=0.0006). Further adjustment for hsCRP attenuated the association which was no longer statistically significant (p trend=0.33). In joint models examining combined levels of GlycA and hsCRP, CVD risk was highest when both GlycA and hsCRP were elevated: fully-adjusted HR 1.39 (1.13-1.71), p=0.002
Conclusion: A novel protein glycan derived biomarker, GlycA, was associated with a graded increase in the risk of incident CVD events in this prospective study of initially healthy women in a manner similar to hsCRP. The association of GlycA with CVD was attenuated after adjusting for hsCRP, consistent with a possible role for protein glycans in inflammation and CVD
- © 2013 by American Heart Association, Inc.