Abstract 18588: Baseline Neutrophil/Lymphocyte Ratio Predicts Recurrences After Radiofrequency Catheter Ablation: Results From Prospective Study on Paroxysmal Atrial Fibrillation
Introduction: Inflammation and atrial fibrillation (AF) are often associated. Whether Neutrophil Lymphocyte Ratio (NLR) affects the radiofrequency catheter ablation outcome is unknown. The aim of this study is to evaluate baseline NLR as the inflammatory predictor of ablation outcome in Paroxysmal AF (PAF) patients.
Method: One hundred seventy five PAF patients undergoing radiofrequency catheter ablation were selected for the study and baseline hematological parameter were evaluated with differential cell count one day prior to ablation. All the patients underwent pulmonary vein antrum isolation and extensive follow-up.
Result: Out of 165 patients with paroxysmal AF, 44 (25.1%) patients develop recurrence after average follow-up of 16 ± 8 months. Baseline NLR was high in recurrence patients. (NLR=3.2 ±0.6 vs. 2.59 ± 0.8, p<0.001). After adjusting for age,gender,coronary artey disease , LA Size and high blood pressure, baseline NLR was found to be a significant predictor of recurrence [HR =1.99 (1.33, 2.96), p=0.001]. Using the cut-off value of 3.08, baseline NLR predicts the recurrence with sensitivity of 72.5% and specificity of 78.6%.
Conclusion: This prospective study shows that baseline NLR is useful inflammatory marker in predicting the recurrence of PAF and in patients with more than 3.08 baseline NLR have high chance of recurrence.
- © 2013 by American Heart Association, Inc.