Abstract 18567: Enhancement of Collaterals by Resveratrol in a Rabbit Model of Hind Limb Ischemia
Background: Resveratrol, a naturally occurring phytoalexin induced cardio angiogenic effects. It is not recognized to induce collaterals in limb ischemia.
Methods: Rabbits were assigned into:1) ischemic , 2) ischemic + Resveratrol. (Loading s.c dose 2.5 mg/kg, followed by 2.5 mg/day/orally x 28 days) and 3) ischemic + LY294002 (3-phosphatidyl inositol (PI3) kinase inhibitor) + Resveratrol. Limb ischemia was induced as described .
Results/conclusions: Resveratrol produced an increase in limb blood pressure ratio by 40% and angiographic score. Angiogenesis detected by CD31 immunostaining and upregulation of eNOS protein expression. LY294002, attenuated collaterals and angiogenesis.
Conclusions: reveratrol enhanced micro and macrocollateral development in ischemic limbs via Akt/PI3-kinase pathway and eNOS providing a possible therapeutic potential for ischemic limbs. References: Bradamante S, Barenghi L, Villa A. Cardiovasc Drug Rev 2004; 22: 169-188. Takeshita S, Rossow ST, Kearney M, et al. J Clin Invest 1994; 93: 662-670.
- © 2013 by American Heart Association, Inc.