Abstract 18487: Characteristics and Outcomes of Patients With Severe Aortic Stenosis (Peak Gradients > 125 mm Hg)
Background: Limited data exists about the unique echocardiographic characteristics of patients with very high gradient severe aortic stenosis (VHG-SAS). We sought to determine if there are differences in left ventricular hypertrophy severity, ejection fraction (EF), and coronary artery disease (CAD) status in patients with VHG-SAS compared to severe AS patients with lower gradients.
Methods: We identified patients with greater than 125 mm Hg peak gradients defined as VHG-SAS and patients with peak gradients between 64-125 mm Hg defined as high gradient severe AS (HG-SAS) evaluated between 1994 and 2011from our echocardiographic database. We then propensity matched these patients based on age and gender and compared their echocardiographic characteristics.
Results: 340 patients with HG-SAS and 212 patients with VHG-SAS were identified. Matched pairs of 212 patients were analyzed for a variety of baseline comorbidities and echocardiographic parameters (Table).
Conclusions: Patients with VHG-SAS have fewer cardiac comorbidities (CAD, Mitral regurgitation, Depressed EF, Diabetes, Hypertension) compared to HG-SAS patients. Furthermore, patients with VHG-SAS have a smaller LV Size and greater wall thickness suggesting an adequate compensatory response to pressure overload.
- © 2013 by American Heart Association, Inc.