Abstract 18413: Systolic Circumferential Strain Derived From Feature-Tracking Cardiovascular Magnetic Resonance Predicts Survival After Cardiac Resynchronization Therapy
Objective: The clinical outcome of cardiac resynchronization therapy (CRT) is variable. Feature-tracking cardiovascular magnetic resonance (FT-CMR) allows quantification of myocardial strain using a routine CMR scan. We hypothesized that pre-implant peak systolic circumferential strain (Ecc) predicts survival after CRT.
Methods: In this prospective study, 98 patients (age: 66 ± 12 yrs, LVEF: 24 ±11%, QRS: 145 ± 30ms) had pre-implant assessment of peak systolic Ecc from the mid cavity LV short-axis slice. This measure, which involved 1.2 ± 0.3 min of post-processing, was assessed in relation to all cause mortality.
Results: The mean peak systolic Ecc was 7.5 ± 5.0% amongst the entire cohort. 30 patients died over a follow-up of 3.9 ± 2.4 yrs (mean ± SD). Above an optimum cut-off of 10%, Ecc, predicted survival after CRT (Chi-squared: 5.37, log-rank p = 0.01; area under the receiver-operator characteristic curve: 0.67, 95% CI 0.58 - 0.79, p = 0.003).
Conclusion: The rapid assessment of pre-implant peak systolic Ecc derived from FT-CMR predicts survival after CRT.
- © 2013 by American Heart Association, Inc.