Abstract 18146: Increased Physical Activity is Associated With Lower Risk of Non Alcoholic Fatty Liver Disease Across Spectrum of Cardiometabolic Risk
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been linked with increased cardiovascular risk. Its prevalence is associated with increase in obesity and insulin resistance. Although physical activity (PA) and life style modification are often recommended to treat NAFLD, the benefit across metabolic risk spectrum is unclear. We aimed to evaluate the relationship of PA and NAFLD independent of the metabolic syndrome (MS).
METHODS: We evaluated 5,743 healthy Brazilian subjects (43±10 years, 79% males) without clinical coronary heart disease between November 2008 and July 2010. NALFD was ultrasound diagnosed and PA was assessed using the International Physical Activity Questionnaire (IPAQ) scale. MS was classified with the IDF criteria. In hierarchical regression models, we evaluated for an independent association of NAFLD and physical activity (PA).
RESULTS: The prevalence of NAFLD was 36% (n=2,075) and 1,152 (20%) had metabolic syndrome. NALFD was significantly higher in those with MS (74%) vs those without MS (26%), p<0.001. Overall 1,304 (23%) individuals were sedentary and 1,987(35%) had minimal activity. The prevalence of NALFD decreased significantly with increasing levels of PA reported (sed: 45%, minimally active: 38%, active= 30%, p<0.001). As shown in table below, after adjusting for confounding variables, higher activity levels was 16-31% less likely associated with NALFD. The benefit appeared to be extend to individuals with and without MS,
Conclusions: PA presents a dose response association with hepatic steatosis independent of the MS. The benefits of PA is not only relevant in MS individuals but should also be emphasized in a non-MS population
- © 2013 by American Heart Association, Inc.