Abstract 17981: Quantitative High Efficiency SPECT With Cadmium-Zinc-Telluride and Dedicated Parallel Collimation System in Obese Patients: A Result From a Multi-Center Study
Background: Obesity is a significant and independent risk factor for cardiovascular disease, and assessing ischemia in obese patients is clinically important but often difficult due to imaging artifacts. We evaluated the diagnostic performance of quantitative high efficiency SPECT (HE-SPECT) with cadmium-zinc-telluride and dedicated parallel collimation system in obese patients for detection of coronary artery disease (CAD) in comparison to invasive coronary angiography (ICA).
Methods: A total of 67 consecutive obese patients [body mass index (BMI) ≥35 kg/m2; mean BMI 41.0±6.2 kg/m2, maximum 68.1 kg/m2] without known CAD who had ICA within 6 months of HE-SPECT at 3 centers were studied. Quantitative stress total perfusion deficit (TPD) and semi-quantitative visual analysis [summed stress score (SSS)] were performed. The diagnostic performance of HE-SPECT was analyzed as ICA standard. Stenosis of ≥50% by ICA was considered obstructive.
Results: Obstructive CAD was found in 39 patients. Sensitivity/specificity/accuracy was 80%/82%/81% for stress TPD and 82%/75%/79% for SSS. Are under the receiver-operating-characteristic curve was 0.87 for stress TPD and 0.84 for SSS. High diagnostic performance was observed in both stress TPD and SSS.
Conclusion: In obese patients, HE-SPECT with cadmium-zinc-telluride and dedicated parallel collimation system had high diagnostic accuracy for detection of CAD by both quantitative and visual analysis.
- © 2013 by American Heart Association, Inc.