Abstract 17969: Physical Activity is Associated With Lower Prevalence of Elevated High Sensitivity C-Reactive Protein in Overweight and Obese, but Not in Normal Weight Individuals
Background: Obesity and sedentary lifestyles have been associated with increased risk of cardiovascular disease (CVD). However, it is unclear whether the benefit of physical activity (PA) is independent of obesity status. We aimed to assess the impact of physical activity on vascular inflammation in normal weight, overweight and obese individuals.
Methods: This large cross-sectional study included 4852 healthy Brazilian participants. Participants were categorized as normal weight ( BMI 30). Physical activity was assessed by International Physical Activity Questionnaire (IPAQ) and was divided into sedentary or active categories for primary analysis and into three categories for secondary analysis (sedentary, little and moderate to severe). Elevated subclinical vascular inflammation was considered a high-sensitivity C-Reactive protein (hs-CRP) level ≥3.
Results: In our study population, 39% were normal weight, 45% were overweight and 17% were obese.. The prevalence of hs-CRP≥3 mg/dl across these was 13%, 19%, and 36% respectively (p<0.001). In addition prevalence of elevated hsCRP was significantly lower with increasing PA levels (25%,20% and 15%, p<0.001). Any PA level was associated with lower odds of elevated hs-CRP in overweight (0.74 (0.58-0.95) p=0.017) and obese (0.70 (0.52-0.96) p=0.025) individuals but not in normal weight individuals (1.00 (0.72-1.41) p=0.966) (Table). Furthermore, the greatest benefit of moderate to severe PA was noted in obese individuals followed by overweight individuals.
Conclusion: The effect of physical activity on systemic inflammation is modified by the presence of obesity. Obese and overweight individuals may derive a greater benefit from PA than normal weight individuals in reducing systemic inflammation and CVD risk. Normal weight individuals do not seem to obtain a significant reduction in inflammation from any level of physical activity in our population.
- © 2013 by American Heart Association, Inc.