Abstract 17919: What Is the Normal Aortic Size in Turner Syndrome?
INTRODUCTION: Turner Syndrome (TS) is an independent risk factor for aortic dilation and dissection. We studied other potential determinants of aortic size in a large cohort of TS subjects in order to define a TS-based standard for aortic dimensions throughout the lifespan.
METHODS: Subjects who underwent operation for aortopathy or had aortic dissection were excluded. From 2003 to 2011 echocardiographic images of the aorta were obtained and measurements performed at eight levels of the aorta during meetings of the Turner Syndrome Society of the United States. Bivariable and multivariable linear regression analyses were performed to assess the impact of risk factors including karyotype, age, body mass index, bicuspid aortic valve (BAV), blood pressure, history of renal disease, thyroid disease, or growth hormone therapy. Repeated measures were used to determine normal growth velocity of the aorta.
RESULTS: 631 echocardiograms were performed in 400 subjects ages 2 to 66 years. For the entire cohort mean values, 5th and 95th percentile prediction limits were determined at each aortic level as a function of body surface area. For example, data for the level of the ascending aorta is shown below. BAV significantly affected aortic size at all ages and levels.
CONCLUSIONS: This is the largest longitudinal cohort study of aortic size in TS. These normative data will be useful in clinical practice.
- © 2013 by American Heart Association, Inc.