Abstract 17910: The Relationship Between Depressive Symptoms, Oxidative Stress, and Arterial Stiffness in Women
Background: Women have higher prevalence of affective disorders, but the mechanisms by which depressive symptoms confer excessive CVD risk in women remain unknown. We investigated the relationship between depressive symptoms and subclinical CVD in women, with the hypothesis that depression will be associated with cardiometabolic abnormalities, oxidative stress burden and increased arterial stiffness.
Methods: 451 university employees (47±10 years, 70% Caucasian) completed the Beck Depression Inventory-II (BDI) survey, and reported previous history of depression. Anthropomorphic measurements, lipid profile and C-reactive protein (CRP) levels were obtained. Oxidative stress was assessed as plasma cystine and arterial stiffness and wave reflections by radial applantation tonometry-derived central augmentation index (AIX) and subendocardial viability ratio (SEVR).
Results: The BDI score (mean 5.9±5.7) decreased with age (r=-0.1, p=0.01). Women with a history of depression (22.8%, 46±11 years) were more often diabetic (11% vs. 5%., p=0.009), hyperlipidemic (32% vs. 23% p=0.01), had higher heart rate (65±9 vs. 61±8, p=0.009), and higher body fat (39±10% vs. 34±8%, p=0.04). Moreover, women without a history of depression but who reported mild or moderate depressive symptoms (BDI score ≥ 14, N=58) had higher cystine levels (89±21 vs. 84±18 units, p=0.002), AIX (27±18 vs. 22±13, p=0.02) and lower SEVR (164±28 vs. 173±25, p<0.001) than those who did not. In all subjects, following multivariable adjustment for age, BMI, race, heart rate, blood pressure, CVD risk factors, history of depression, current anti-depressant therapy and CRP levels, higher BDI scores remained significantly associated with higher plasma cystine levels (R=0.61, β=0.54, p=0.02), increased AIX (R=0.61, β=0.25, p=0.002) and lower SEVR (R=0.59, β=-8.5, p<0.001).
Conclusion: Women with a history of depression have worse cardiometabolic risk profiles. Even mild depressive symptoms are associated with increased oxidative stress and arterial stiffening, highlighting potential mechanisms by which depression confers risk of CVD. Whether anti-depressant therapy will improve oxidative stress and vascular function needs further study.
- © 2013 by American Heart Association, Inc.